860506P
Avanti
C6 神经酰胺 (d18:1/6:0)
Avanti Research™ - A Croda Brand
别名:
N-己酰-D-赤-鞘氨醇
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 10 mg (860506P-10mg)
pkg of 1 × 5 mg (860506P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+
InChI key
NPRJSFWNFTXXQC-VHEBQXMUSA-N
一般描述
C6神经酰胺（d18:1/6:0）是一种具有细胞通透性的短链神经酰胺。它包含通过酰胺键与脂肪酰基链相连的氨基醇链。
应用
C6神经酰胺（d18:1/6:0）已被作为化疗药物用于测试其在乳腺癌细胞和卵巢癌细胞系中的抗肿瘤作用。它还被用于测试癌细胞中的化疗增敏作用。
生化/生理作用
C6神经酰胺（d18:1/6:0）可参与到增殖抑制和细胞凋亡诱导。当与酸性神经酰胺酶抑制剂DM102，即[(2R,3Z)-N-(1-羟基十八烷基-3-en-2-基）新戊酰酰胺]结合使用时，可有助于人乳腺癌细胞系的细胞死亡。C6神经酰胺可作为化疗的一种辅助手段。它可通过AKT（丝氨酸/苏氨酸特异性蛋白激酶）去磷酸化和α-微管蛋白乙酰化引发抗肿瘤作用。
包装
5 mL琥珀色玻璃螺旋盖小瓶（860506P-10mg）
5 mL琥珀色玻璃螺旋盖小瓶（860506P-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth
Flowers M, et al.
Breast Cancer Research and Treatment, 133(2), 447-458 (2012)
Q-y Zhu et al.
Cell death & disease, 2, e117-e117 (2011-03-04)
Histone deacetylase inhibitors (HDACIs) have shown promising anti-tumor effects for a variety of malignancies, however, many tumors are reportedly resistant to them. In this study, we made a novel discovery that co-administration of HDACIs (Trichostatin A (TSA) and others) and
C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: a mechanism study
Yang L, et al.
Experimental Cell Research, 332(1), 47-59 (2015)
Mechanisms involved in exogenous C2-and C6-ceramide-induced cancer cell toxicity
Fillet M, et al.
Biochemical Pharmacology, 65(10), 1633-1642 (2003)
Short-chain C6 ceramide sensitizes AT406-induced anti-pancreatic cancer cell activity
Zhao X, et al.
Biochemical and Biophysical Research Communications, 479(2), 166-172 (2016)
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