G2417
甲磺酸加贝酯
analytical standard, for drug analysis
别名:
4-(6-胍基己酰氧基)苯甲酸乙酯甲磺酸盐, 4-[[6-[(氨基亚氨基甲基)氨基]-1-氧己基]氧]苯甲酸乙酯 甲磺酸盐, 福耶
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关于此项目
经验公式（希尔记法）:
C16H23N3O4 · CH4O3S
化学文摘社编号:
分子量:
417.48
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI key
DNTNDFLIKUKKOC-UHFFFAOYSA-N
SMILES string
CS(O)(=O)=O.CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1
InChI
1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)
form
solid
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
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General description
Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases, which finds therapeutic applications in the treatment of disseminated intravascular coagulation and pancreatitis. It also plays the role of an anticoagulant in hemodialysis therapy.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Dalya M Lateef et al.
Peptides, 32(6), 1289-1295 (2011-04-02)
Camostat mesilate (or mesylate) releases endogenous cholecystokinin (CCK) or CCK-58, the only detectable endocrine form of CCK in the rat, and reduces cumulative food intake by activating CCK(1) receptor. However, the literature lacks meal pattern analysis and an appropriate dose-response
Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug.
Erba F, et al.
Biochemical Pharmacology, 61(3), 271-276 (2001)
Dalya M Lateef et al.
Physiology & behavior, 105(3), 829-834 (2011-11-04)
We have shown that vagotomy (VGX) attenuates the reduction of meal size (MS) produced by cholecystokinin (CCK) -8 and -33 and that celiaco-mesenteric ganglionectomy (CMGX) attenuates the prolongation of the intermeal interval (IMI) produced by CCK-33. Here, we report the
Gabexate mesylate inhibition of serine proteases: Thermodynamic and computer?graphics analysis.
Menegatti E, et al.
Journal of Pharmaceutical Sciences, 75(12), 1171-1174 (1986)
James A Reihill et al.
Biomolecules, 10(4) (2020-04-02)
Epithelial barrier dysfunction, characteristic of allergic airway disease may be, at least in part, due to the action of allergen-associated protease activities. Cockroach allergy is a major global health issue, with cockroaches containing considerable serine trypsin-like protease (TLP) activity. The
商品
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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