CN

C1251

Sigma-Aldrich

(+)-儿茶素 水合物

≥98% (HPLC), powder

别名:
(2R,3S)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇, (+)-儿茶精-3
Empirical Formula (Hill Notation):
C15H14O6 · xH2O
CAS号:
分子量:
290.27 (anhydrous basis)
Beilstein/REAXYS Number:
3595244
EC 号:
MDL编号:
PubChem化学物质编号:

质量水平

200

测定

≥98% (HPLC)

形式

powder

颜色

yellow to yellow with tan cast

mp

175-177 °C (anhydrous) (lit.)

溶解性

ethanol: 50 mg/mL

储存温度

2-8°C

SMILES string

[H]O[H].O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3

InChI

1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1

InChI key

OFUMQWOJBVNKLR-NQQJLSKUSA-N

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一般描述

儿茶素是植物化学物质,在黑葡萄、桃子、草莓和蚕豆中含量丰富。儿茶素有各种形式,如儿茶素、表儿茶素、表儿茶素没食子酸酯、表焙儿茶素和表没食子儿茶素没食子酸酯。

应用

(+)-水合儿茶素已用于以下情形:
  • 作为多酚标准品,测定红葡萄酒副产物中的多酚总量
  • 作为添加剂,通过三重进料批量方法研究对体外甲烷生产和底物降解的效果
  • 作为底物,测定L. plantarum CECT 748T 14重组鞣酸酶对儿茶素的活性

包装

5, 10 g in poly bottle

生化/生理作用

一种植物来源的抗氧化性黄酮类化合物;自由基清除剂,可在各种生物系统中防止自由基介导的损伤。例如,在生理pH条件下,儿茶素可抑制羟基自由基介导的DNA链断裂。它还可以防止人体血浆氧化。它延迟了内源性脂溶性抗氧化剂的消耗并抑制脂质氧化。儿茶素还可以作为脂肪酸合酶的抑制剂。

特点和优势

该化合物也是Sigma药理活性化合物库(LOPAC®1280)的一部分,该化合物库是一个具有生物学注释的高品质、可即时筛选化合物的集合。 点击此处 ,了解更多信息。

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

象形图

Exclamation mark

警示用语:

Warning

危险声明

靶器官

Respiratory system

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Hadeer M Ezzat et al.
International journal of pharmaceutics, 565, 488-498 (2019-05-18)
Catechin hydrate is a phytopharmaceutical with promising anticancer effects but poor bioavailability. This study aimed to elaborate catechin loaded chitosan-tethered liposomes (chitosomes) to enhance catechin oral bioavailability. Nanocarriers were optimized via ethanol injection method followed by physicochemical, ex vivo and...
Christine Ziegler et al.
Molecular microbiology, 78(1), 13-34 (2010-10-07)
Increases in the environmental osmolarity are key determinants for the growth of microorganisms. To ensure a physiologically acceptable level of cellular hydration and turgor at high osmolarity, many bacteria accumulate compatible solutes. Osmotically controlled uptake systems allow the scavenging of...
Nutrition and Health Info Sheet: Catechins (2008)
S B Lotito et al.
Free radical biology & medicine, 24(3), 435-441 (1998-01-23)
Based on the recognized capacity of (+)-catechin (CTCH) to prevent free radical-mediated damage in different biological systems, its role in the protection of human plasma from oxidation was investigated. Samples of human blood plasma were incubated with 50 mM AAPH...
J Ueda et al.
Archives of biochemistry and biophysics, 333(2), 377-384 (1996-09-15)
The reactivities of various antioxidative compounds including catechol derivatives and endogenous radical scavengers toward hydroxyl radical (.OH) were investigated by an electron spin resonance-spin trapping method, thiobarbituric acid method, and DNA strand scission assay. Hydroxyl radical was generated by both...
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