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Merck
CN

S9009

Sar-Pro-Arg p-nitroanilide dihydrochloride

thrombin substrate, ≥97% (HPLC), powder

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关于此项目

经验公式（希尔记法）:
C20H30N8O5 · 2HCl
化学文摘社编号:
75241-23-5
分子量:
535.42
UNSPSC Code:
12352204
PubChem Substance ID:
24899823
NACRES:
NA.32
MDL number:
MFCD00058168

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产品名称

Sar-Pro-Arg p-nitroanilide dihydrochloride, thrombin substrate

SMILES string

Cl.CNCC(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc(cc2)N(=O)=O

InChI

1S/C20H30N8O5.ClH/c1-23-12-17(29)27-11-3-5-16(27)19(31)26-15(4-2-10-24-20(21)22)18(30)25-13-6-8-14(9-7-13)28(32)33;/h6-9,15-16,23H,2-5,10-12H2,1H3,(H,25,30)(H,26,31)(H4,21,22,24);1H

InChI key

KMSNYOSWLIQVAN-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

solubility

water: 25 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

Quality Level

300

General description

Chromogenic substrate for thrombin.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
028K5100V
028K5100
123K5007
106K5003
086K5011

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A Duncan et al.
Clinical chemistry, 31(6), 853-855 (1985-06-01)
Automated procedures involving a chromogenic substrate sensitive to thrombin-sarcosine-Pro-Arg p-nitroanilide were compared with conventional tests for prothrombin times and activated partial thromboplastin times (APTT) and with specific assays for factors V, VII, VIII, IX, X, XI, and XII. The reproducibility
Usman Bacha et al.
Chemical biology & drug design, 72(1), 34-49 (2008-07-10)
Coronaviruses comprise a large group of RNA viruses with diverse host specificity. The emergence of highly pathogenic strains like the SARS coronavirus (SARS-CoV), and the discovery of two new coronaviruses, NL-63 and HKU1, corroborates the high rate of mutation and

实验方案

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

牛血浆凝血酶

凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。

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