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112631

2-甲氧基-4-硝基苯胺

Name: 2-甲氧基-4-硝基苯胺
Brand: ALDRICH

98%

别名:

4-硝基邻茴香胺

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关于此项目

线性分子式:

CH₃OC₆H₃(NO₂)NH₂

化学文摘社编号:

97-52-9

分子量:

168.15

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24847104

EC Number:

202-588-6

Beilstein/REAXYS Number:

879619

MDL number:

MFCD00007363

Assay:

98%

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属性

Quality Level

100

assay

98%

mp

140-142 °C (lit.)

SMILES string

COc1cc(ccc1N)[N+]([O-])=O

InChI

1S/C7H8N2O3/c1-12-7-4-5(9(10)11)2-3-6(7)8/h2-4H,8H2,1H3

InChI key

GVBHRNIWBGTNQA-UHFFFAOYSA-N

说明

General description

2-甲氧基-4-硝基苯胺由于分子量小，因此是 CYP1A2 的重要诱导剂。

Application

2-甲氧基-4-硝基苯胺作为光度试剂，用于测定乙炔雌醇（ETE），乙炔雌醇是一种半合成的雌激素，广泛用于口服避孕药。

Biochem/physiol Actions

在 Harlan Sprague Dawley 大鼠和 B6C3F（1）/N 小鼠中，2-甲氧基-4-硝基苯胺（MNA）通过苯环的羟基化作用代谢生成 6-羟基 MNA。

pictograms

GHS08,GHS07,GHS09

signalword

Warning

hcodes

H302,H351,H411

pcodes

P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

危险化学品

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历史批次信息供参考:

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Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice.

James M Mathews et al.

Xenobiotica; the fate of foreign compounds in biological systems, 42(12), 1213-1224 (2012-06-26)

The disposition of 2-Methoxy-4-nitroaniline (MNA) was investigated in male and female Harlan Sprague Dawley rats and B6C3F(1)/N mice following oral, intravenous, and dermal exposure to [(14)C]MNA at 2, 15, or 150 mg/kg. Clearance of MNA was investigated in male and

2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver.

M Degawa et al.

Cancer letters, 96(1), 95-98 (1995-09-04)

Male F344 rats were treated with a chemical (aniline, nitrobenzene, 2-methoxy-p-phenylenediamine, 2-methoxy-4-nitroaniline or 2-methoxy-4-nitroazobenzene) produced by the azo-reduction and/or N-oxidation of 2-methoxy-4-amino-azo-benzene, a selective inducer of cytochrome P450IA2 (CYP1A2), and their effects on the induction of CYP1A enzymes in the

Evaluation of 2-methoxy-4-nitroaniline (MNA) in hypersensitivity, 14-day subacute, reproductive, and genotoxicity studies.

Rachel P Frawley et al.

Toxicology, 441, 152474-152474 (2020-05-08)

2-Methoxy-4-nitroaniline (MNA), an intermediate in the synthesis of azo dyes used in textiles and paints, is structurally similar to carcinogenic anilines. Human exposure occurs primarily in the occupational setting through handling of dye dust, and through use and disposal of

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全球贸易项目编号

货号	GTIN
112631-100G	04061838700100