122408
1,2,3,4-四氢-1-萘酚
97%
别名:
α-四氢萘酚
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关于此项目
经验公式（希尔记法）:
C10H12O
化学文摘社编号:
分子量:
148.20
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
208-459-0
Beilstein/REAXYS Number:
2046227
MDL number:
InChI key
JAAJQSRLGAYGKZ-UHFFFAOYSA-N
InChI
1S/C10H12O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10-11H,3,5,7H2
SMILES string
OC1CCCc2ccccc12
assay
97%
form
solid
refractive index
n20/D 1.564 (lit.)
bp
102-104 °C/2 mmHg (lit.)
density
1.09 g/mL at 25 °C (lit.)
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Application
1,2,3,4-Tetrahydro-1-naphthol was used as chiral probe to examine the role of three aromatic residues in enzyme-substrate interactions at the sulfuryl acceptor binding site of aryl sulfotransferase IV enzyme.
General description
(R)-(-)-enantiomer of 1,2,3,4-Tetrahydro-1-naphthol is a substrate for aryl sulfotransferase (AST) IV enzyme and (S)-(+)-1,2,3,4-tetrahydro-1-naphthol is a competitive inhibitor of AST IV-catalyzed sulfation of 1-naphthalenemethanol. It is the major urinary metabolite of tetralin.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Vyas Sharma et al.
Journal of medicinal chemistry, 45(25), 5514-5522 (2002-12-03)
Comparative Molecular Field Analysis (CoMFA) methods were used to produce a 3D-QSAR model that correlated the catalytic efficiency of rat hepatic aryl sulfotransferase (AST) IV, expressed as log(k(cat)/K(m)), with the molecular structures of its substrates. A total of 35 substrate
Jonathan J Sheng et al.
Drug metabolism and disposition: the biological fate of chemicals, 32(5), 559-565 (2004-04-22)
Aryl sulfotransferase (AST) IV (also named tyrosine-ester sulfotransferase and ST1A1) is a major phenol sulfotransferase in the rat, and it catalyzes the sulfation of many drugs, carcinogens, and other xenobiotics that contain phenol, benzylic alcohol, N-hydroxy arylamine, and oxime functional
Metabolism of tetralin and toxicity of Cuprex in man.
D E Drayer et al.
Drug metabolism and disposition: the biological fate of chemicals, 1(3), 577-579 (1973-05-01)
W F Leebaw et al.
The Journal of clinical endocrinology and metabolism, 47(3), 480-487 (1978-09-01)
Although the role of the neurotransmitter, dopamine (DA), in the regulation of PRL has been well documented, controversy exists regarding its participation in the regulation of the other pituitary hormones. Consequently, we infused DA into six healthy male subjects (ages
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