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安全信息

125180

Sigma-Aldrich

1-(3-氯苯基)哌嗪 盐酸盐

99%

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别名:
m-CPP
经验公式（希尔记法）:
C10H13ClN2 · xHCl
CAS号:
65369-76-8
分子量:
196.68 (free base basis)
EC 号:
265-718-0
MDL编号:
MFCD00039032
PubChem化学物质编号:
24847652
NACRES:
NA.22

检测方案

99%

形式

powder

mp

210-214 °C (dec.) (lit.)

溶解性

methanol: soluble

SMILES string

Cl.Clc1cccc(c1)N2CCNCC2

InChI

1S/C10H13ClN2.ClH/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13;/h1-3,8,12H,4-7H2;1H

InChI key

MHXPYWFZULXYHT-UHFFFAOYSA-N

Gene Information

rat ... Htr1a(24473)

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相关类别

一般描述

1-(3-Chlorophenyl)piperazine hydrochloride is sold as Ecstasy mimic tablets and is the major metabolite of the antidepressant medications trazodone and nefazodone.

应用

1-(3-Chlorophenyl)piperazine hydrochloride (CPP) has been used in determination of designer piperazines in urine specimens using GC-MS and LC-ESI-MS. CPP has been used to investigate the in vitro efficacy of newly synthesized compounds such as fluoroquinolones (norfloxacine and lomefloxacine) against Philasterides dicentrarchi .

生化/生理作用

1-(3-Chlorophenyl)piperazine induces hypophagia in food-deprived and freely feeding rats. CPP has affinity for 11 neurotransmitter receptor binding sites in human brain membranes.
5-HT2c 羟色胺受体激动剂；曲唑酮的代谢物。

象形图

Exclamation mark
GHS07

警示用语：

Warning

预防措施声明

P261 - P305 + P351 + P338

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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A Hamik et al.
Biological psychiatry, 25(5), 569-575 (1989-03-01)
The affinity of 1-(m-chlorophenyl)piperazine (mCPP) for 11 neurotransmitter receptor binding sites was determined in human brain membranes. mCPP is essentially equipotent at all 5-hydroxytryptamine (5-HT) receptor subtypes (IC50 values ranging from 360 to 1300 nM). The drug displays similar affinity
G A Kennett et al.
British journal of pharmacology, 103(4), 2016-2020 (1991-08-01)
1. 1-3(Chlorophenyl)piperazine (mCPP) (5 mg kg-1, i.p.) inhibited 2 h food intake in rats previously deprived of food for one day. Ten 5-hydroxytryptamine (5-HT) antagonists given s.c. opposed this hypophagic response. Calculated ID50 values correlated significantly with reported affinities (r
Horst Schicknick et al.
Cerebral cortex (New York, N.Y. : 1991), 18(11), 2646-2658 (2008-03-07)
Previous studies in the auditory cortex of Mongolian gerbils on discrimination learning of the direction of frequency-modulated tones (FMs) revealed that long-term memory formation involves activation of the dopaminergic system, activity of the protein kinase mammalian target of rapamycin (mTOR)
A Paramá et al.
Diseases of aquatic organisms, 62(1-2), 97-102 (2005-01-15)
Philasterides dicentrarchi is a histiophagous ciliate that causes severe losses in turbot and sea bass farming. This study investigated the in vitro efficacy against P. dicentrarchi of 85 newly synthesized compounds and 12 commercial compounds, of which 2 are fluoroquinolones
Shawn P Vorce et al.
Journal of analytical toxicology, 32(6), 444-450 (2008-07-26)
Designer piperazines, such as 1-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)-piperazine (TFMPP), are widely available and have become popular party drugs throughout the world. Used in many countries as legal alternatives to methamphetamine and ecstasy, these designer piperazines exhibit several of the same
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