Merck
CN
所有图片(1)

文件

136565

Sigma-Aldrich

N-(3-氨基丙基)-2-吡咯烷酮

technical grade

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所有图片(1)
经验公式（希尔记法）:
C7H14N2O
CAS号:
7663-77-6
分子量:
142.20
EC 号:
231-632-7
MDL编号:
MFCD00003201
PubChem化学物质编号:
24848286

等级

technical grade

形式

liquid

杂质

2% 2-pyrrolidinone

折射率

n20/D 1.5 (lit.)

bp

120-123 °C/1 mmHg (lit.)

密度

1.014 g/mL at 25 °C (lit.)

SMILES string

NCCCN1CCCC1=O

InChI

1S/C7H14N2O/c8-4-2-6-9-5-1-3-7(9)10/h1-6,8H2

InChI key

HJORCZCMNWLHMB-UHFFFAOYSA-N

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相关类别

一般描述

N-(3-Aminopropyl)-2-pyrrolidinone (PYR) conjugates (VPA-PYR) of valproic acid (VA) have been investigated for their anticonvulsant activity in mice. It is the γ-lactam form of isoputreanine.

应用

N-(3-Aminopropyl)-2-pyrrolidinone was used in the simultaneous determination of total polyamines and three of their non−α− amino acid metabolites in urine by capillary gas-chromatographic method with nitrogen-phosphorus detection.

其他说明

含有不定量的 1,5-二氮杂双环[4.3.0]壬-5-烯（产品目录号136581）

象形图

Corrosion
GHS05

警示用语：

Danger

危险声明

H314

危险分类

Skin Corr. 1B

储存分类代码

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

闪点(°F)

235.4 °F - closed cup

闪点(°C)

113 °C - closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Ofer Spiegelstein et al.
Epilepsy research, 57(2-3), 145-152 (2004-03-12)
Valproic acid (VPA) is an effective antiepileptic medication, the use of which in females of childbearing age is complicated by its ability to induce birth defects, including neural tube defects (NTDs), in exposed embryos. In experimental settings, VPA reproducibly induces
N Seiler et al.
The Biochemical journal, 208(1), 189-197 (1982-10-15)
A high-pressure-liquid-chromatographic method suitable for the separation and sensitive detection of putreanine and isoputreanine is described. This method allowed us to study the formation of the metabolites of the oxidative deamination of spermidine and N1-acetylspermidine. Administration of spermidine trishydrochloride to
N Seiler et al.
The International journal of biochemistry, 15(7), 907-915 (1983-01-01)
Normal human and rat urine contain N-(3-aminopropyl)pyrrolidin-2-one. This compound was identified by its chromatographic behaviour on a reversed phase column, by thin-layer chromatography of its dansyl derivative, and by mass spectrometry. Evidence for the presence of conjugates of N-(3-aminopropyl)pyrrolidin-2-one in
Andre P Martinez et al.
Biomacromolecules, 18(6), 2000-2011 (2017-05-20)
A series of biodegradable drug delivery polymers with intrinsic multifunctionality have been designed and synthesized utilizing a polyphosphazene macromolecular engineering approach. Novel water-soluble polymers, which contain carboxylic acid and pyrrolidone moieties attached to an inorganic phosphorus-nitrogen backbone, were characterized by
F A Muskiet et al.
Clinical chemistry, 30(5), 687-695 (1984-05-01)
A capillary gas-chromatographic method with nitrogen-phosphorus detection is used here to simultaneously determine 1,3-diaminopropane, putrescine, cadaverine, spermidine, spermine, isoputreanine , putreanine , and N-(3-aminopropyl)-N'-(2-carboxyethyl)-1,4- diaminobutane in urine. After acid hydrolysis the compounds are isolated by adsorption onto silica gel and

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