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Merck
CN

140732

N,N-二甲基甲酰胺二甲缩醛

technical grade, 94%

别名:

1,1-二甲氧基-N,N-二甲氧基, 1,1-二甲氧基三甲胺

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关于此项目

线性分子式:
(CH3)2NCH(OCH3)2
化学文摘社编号:
分子量:
119.16
UNSPSC Code:
12352302
NACRES:
NA.22
PubChem Substance ID:
EC Number:
225-063-3
Beilstein/REAXYS Number:
506020
MDL number:
Assay:
94%
Form:
liquid
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refractive index

n20/D 1.396 (lit.)

bp

102-103 °C/720 mmHg (lit.)

density

0.897 g/mL at 25 °C (lit.)

functional group

amine, ether

InChI key

ZSXGLVDWWRXATF-UHFFFAOYSA-N

InChI

1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3

SMILES string

COC(OC)N(C)C

grade

technical grade

assay

94%

form

liquid

reaction suitability

reaction type: C-C Bond Formation

Quality Level

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Application

N,N-二甲基甲酰胺二甲基缩醛(DMF-DMA)可用作: 
  • 有机催化剂,以通过芳乙烯与缺电子炔烃反应合成1,2-二取代-3,4-二氢萘。       
  • 基本构成要素,以通过亚甲基和氨基的甲酰化制备诸如烯胺和脒等杂环化合物。       
  • 一种试剂,以通过与氯代乙酰胺反应合成1,4-二芳基-哌嗪-2,5-二酮。        
  • 一种试剂,在Me3SiCl存在下,与烯胺和炔属烃一起通过三组分偶联反应制备2,3,4,5-四取代吡啶衍生物。

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 2 - Skin Sens. 1

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

42.8 °F

flash_point_c

6 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

危险化学品
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分析证书(COA)

Lot/Batch Number

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Wim Schepens et al.
Organic letters, 8(19), 4247-4250 (2006-09-08)
A novel series of analogues of calcitriol (1) is developed featuring a spirocyclic central core resulting from C18/C21-connection and C15/C16-deletion (2a, 2b). The synthesis of the key intermediate involves an Eschenmoser rearrangement of an enantiomerically pure bromo-substituted cyclohexenol.
Dimethylformamide dimethyl acetal as a building block in heterocyclic synthesis
Abu-Shanab FA, et al.
Journal of Heterocyclic Chemistry, 46(5), 801-827 (2009)
A highly efficient cycloaddition of vinylarenes with electron-deficient alkynes affording 1, 2-disubstituted-3, 4-dihydronaphthalenes catalysed by N, N-dimethylformamide dimethyl acetal
Jiang J-L, et al.
Organic & Biomolecular Chemistry, 5(12), 1854-1857 (2007)
Synthesis of 1, 4-Diaryl-piperazine-2, 5-diones: New Behavior of N, N-Dimethylformamide Dimethyl Acetal (DMFDMA)
Abu-Shanab FA, et al.
Synthetic Communications, 38(3), 376-382 (2008)
C Rodier et al.
Chirality, 14(6), 527-532 (2002-07-12)
Two different methods of derivatization were studied in order to select and optimize one for the in situ enantiomeric separation of amino acids present in Martian samples. The method, using DMF-DMA [N,N-dimethylformamide dimethyl acetal], is simple and easily automated. However

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