质量水平
方案
97%
mp
217-220 °C (dec.) (lit.)
官能团
bromo
储存温度
2-8°C
SMILES字符串
Brc1nc(Br)c(Br)[nH]1
InChI
1S/C3HBr3N2/c4-1-2(5)8-3(6)7-1/h(H,7,8)
InChI key
JCGGPCDDFXIVQB-UHFFFAOYSA-N
一般描述
2,4,5-Tribromoimidazole(2,4,5-TBI) on condensation with sugar precursors yields 2,4,5-TBI nucleosides.
生化/生理作用
2,4,5-Tribromoimidazole induces poisoning typical of uncouplers of oxidative phosphorylation in rats.
警示用语：
Danger
危险分类
Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
R D Verschoyle et al.
Archives of toxicology, 56(2), 109-112 (1984-12-01)
2,4,5-tribromoimidazole and its 1-n-butylcarboxylate and 1-dimethylcarbamoyl derivatives, when administered to rats, induced poisoning typical of uncouplers of oxidative phosphorylation. At 48 h rats surviving a single toxic dose of 20-60 mg/kg developed permanent incoordination of the hindlimbs in the absence
Kirsten Benkendorff et al.
Natural product research, 18(5), 427-431 (2004-07-14)
From analysis by gas chromatography/mass spectrometry (GC/MS), the presence of either 2,4,5-tribromo-1H-imidazole (1) or 3,4,5-tribromo-1H-pyrazole (2) was tentatively identified in lipophilic extracts from the egg masses of three muricid molluscs. Synthesis of these compounds, followed by comparison of the GC
Tun-Cheng Chien et al.
Journal of medicinal chemistry, 47(23), 5743-5752 (2004-10-29)
A series of polyhalogenated imidazole nucleosides were designed and synthesized as ring-contracted analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) and its 2-bromo analogue (BDCRB) in an effort to explore the spatial limitation of the active pocket(s) in the target protein(s). 2,4,5-Trichloro-, 2-bromo-4,5-dichloro-, and
R D Verschoyle et al.
Toxicology and applied pharmacology, 89(2), 175-182 (1987-06-30)
The trihalogenated imidazoles, trichloroimidazole (TCI), tribromoimidazole (TBI), and triiodoimidazole (TII), are in vitro uncouplers of oxidative phosphorylation with similar activities. Although TCI and TBI are also uncouplers in vivo, some doubt exists for TII, which is much less toxic and
M Muneer et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 44(5), 331-337 (2001-11-07)
The photocatalysed degradation of two selected pesticide derivatives, namely 3-tert-butyl-5-chloro-6-methyluracil (terbacil) and 2,4,5-tribromoimidazole (TBI) has been investigated in aqueous suspensions of titanium dioxide (TiO2) under a variety of conditions employing a pH-stat technique. The degradation was studied by monitoring the
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