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经验公式(希尔记法):
C4H2Cl2N2
化学文摘社编号:
分子量:
148.98
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
214-770-2
Beilstein/REAXYS Number:
111195
MDL number:
产品名称
4,6-二氯嘧啶, 97%
InChI key
XJPZKYIHCLDXST-UHFFFAOYSA-N
InChI
1S/C4H2Cl2N2/c5-3-1-4(6)8-2-7-3/h1-2H
SMILES string
Clc1cc(Cl)ncn1
assay
97%
form
solid
bp
176 °C (lit.)
mp
65-67 °C (lit.)
solubility
95% ethanol: soluble 50 mg/mL, clear to very slightly hazy, colorless to yellow
functional group
chloro
Quality Level
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Application
在 N -取代氮杂杯嘧啶的合成中使用了 [4,6-二氯嘧啶 。它被用作通过串联胺化和 Suzuki-Miyaura 交叉偶联合成双取代嘧啶的起始试剂 。它也用于涉及联芳交叉耦合的联芳嘧啶合成。
General description
4,6-二氯嘧啶的循环伏安图显示三个阴极波,由碳氯键的连续断裂以及嘧啶的还原产生 。
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Tetrahedron, 62, 10055-10055 (2006)
Li-Xia Wang et al.
The Journal of organic chemistry, 75(3), 741-747 (2010-01-02)
A number of N-substituted azacalix[4]pyrimidines were synthesized by two methods. While straightforward condensation reaction between 4,6-dichloropyrimidine and 4,6-bis(alkylamino)pyrimidines gave identically N-substituted azacalix[4]pyrimidines in low yields, a general and moderate-to-high yielding 1 + 3 macrocyclic fragment coupling reaction afforded azacalix[4]pyrimidines that
Richard T Wheelhouse et al.
Journal of medicinal chemistry, 49(17), 5187-5198 (2006-08-18)
Biarylpyrimidines are characterized as selective ligands for higher-order nucleic acid structures. A concise and efficient synthesis has been devised incorporating Suzuki biaryl cross-coupling of dihalopyrimidines. Two ligand series are described based on the parent thioether 4,6-bis[4-[[2-(dimethylamino)ethyl]mercapto]phenyl]pyrimidine (1a) and amide 4,6-bis(4[(2-(dimethylamino)ethyl)carboxamido]phenyl)pyrimidine
Electrochemical reduction of halogenated pyrimidines at mercury cathodes in acetonitrile.
Ji C, et al.
Journal of Electroanalytical Chemistry, 500(1), 3-11 (2001)
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