Merck
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文件

207713

Sigma-Aldrich

1,3-二邻甲苯胍

99%

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别名:
DTG
线性分子式:
(CH3C6H4NH)2C(=NH)
CAS号:
97-39-2
分子量:
239.32
EC 号:
202-577-6
MDL编号:
MFCD00008513
PubChem化学物质编号:
24852467

质量水平

100

检测方案

99%

形式

solid

mp

176-178 °C (lit.)

溶解性

water: soluble 70 mg/mL at 20 °C

SMILES string

Cc1ccccc1NC(=N)Nc2ccccc2C

InChI

1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)

InChI key

OPNUROKCUBTKLF-UHFFFAOYSA-N

Gene Information

human ... EBP(10682)

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相关类别

一般描述

1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

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  5. What is the solubility of Product 207713, 1,3-di-o-tolylguanidine?

    1,3-Di-o-tolylguanidine is soluble in water at 70 micrograms per mL at ambient temperature.

  6. What is the nature of the biological activity of Product 207713, 1,3-di-o-tolylguanidine?

    1,3-Di-o-tolylguanidine is known to be a selective ligand for the sigma site in the mammalian central nervous system. Behavioral changes, such as hypothermia, reduced pain behavior, circling behavior, and decreased locomotor activity in mice and/or rats were observed after intraperitoneal, subcutaneous, intravenous and/or intranigral injection.

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J Maj et al.
Polish journal of pharmacology, 48(4), 379-395 (1996-07-01)
1,3-Di-o-tolylguanidine (DTG), opipramol (OPI) and sertraline (SER), sigma site ligands, were studied in Wistar rats and Albino Swiss mice, mainly with regard to their interaction with dopamine drugs. DTG and SER (at the highest doses only) decreased the spontaneous locomotor
Thibault Mesplède et al.
AIDS (London, England), 29(6), 659-665 (2015-04-08)
In treatment-naive HIV-positive individuals, the integrase strand-transfer inhibitor dolutegravir (DTG) has not been associated with emergent drug-resistance mutations, neither against this drug nor against other antiretroviral drugs that were used in combination with it. This is in contrast to all
F P Monnet et al.
The Journal of pharmacology and experimental therapeutics, 307(2), 705-712 (2003-09-17)
Intracellular calcium concentration ([Ca2+]i) plays a major role in neuronal excitability, especially that triggered by the N-methyl-d-aspartate (NMDA)-sensitive glutamatergic receptor. We have previously shown that sigma1 receptor agonists potentiate NMDA receptor-mediated neuronal activity in the hippocampus and recruit Ca2+-dependent second
Jiping Liu et al.
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Modified nano-TiO2 was prepared by using triethanolamine and tetraisopropyl di (dioctylphosphate) titanate, respectively. Then the poly(p-phenylene benzobisoxazole) (PBO) fibers doped with different additions of modified nano-TiO2 particles were prepared by preparing PBO polymer solution and dry-jet wet spinning technique. Thermogravimetric
Grzegorz Wicher et al.
Journal of neurotrauma, 34(22), 3173-3182 (2017-05-12)
Traumatic brain injury (TBI) is a devastating condition, often leading to life-long consequences for patients. Even though modern neurointensive care has improved functional and cognitive outcomes, efficient pharmacological therapies are still lacking. Targeting peripherally derived, or resident inflammatory, cells that
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