217077
6-羟基-1,3-苯唑硫醇-2-酮
≥98%
别名:
噻克索酮
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关于此项目
经验公式（希尔记法）:
C7H4O3S
化学文摘社编号:
分子量:
168.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
225-653-0
MDL number:
产品名称
6-羟基-1,3-苯唑硫醇-2-酮, ≥98%
solubility
diethyl ether: soluble
95% ethanol: soluble 50 mg/mL, clear to very slightly hazy, colorless to yellow
benzene: soluble
isopropanol: soluble
propylene glycol: soluble
toluene: soluble
water: insoluble
InChI key
SLYPOVJCSQHITR-UHFFFAOYSA-N
InChI
1S/C7H4O3S/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3,8H
SMILES string
Oc1ccc2SC(=O)Oc2c1
assay
≥98%
mp
158-160 °C (lit.)
Quality Level
Application
6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity.
General description
Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 18(14), 3938-3941 (2008-06-24)
Inhibition of 13 mammalian isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), CA I-XV, with thioxolone (6-hydroxy-1,3-benzoxathiol-2-one) and two sulfonamides was investigated. Thioxolone was inefficient for generating isozyme-selective inhibitors, since except for CA I which is inhibited in the
Contact dermatitis to thioxolone.
H Näher et al.
Contact dermatitis, 17(4), 250-251 (1987-10-01)
[Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one (01 1)].
H Goeth et al.
Arzneimittel-Forschung, 19(8), 1298-1304 (1969-08-01)
Contact dermatitis to thioxolone.
J G Camarasa
Contact dermatitis, 7(4), 213-214 (1981-07-01)
Facile regioselective synthesis and antimicrobial activity of heterocycle-phosphor esters.
Abdou WM, et al.
Monatshefte fur Chemie / Chemical Monthly, 145(4), 675-682 (2014)
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