Merck
CN

228435

Sigma-Aldrich

5-溴吡啶-3-羧酸

98%

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别名:
5-溴烟酸
经验公式(希尔记法):
C6H4BrNO2
CAS号:
分子量:
202.01
Beilstein:
115854
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

检测方案

98%

形式

solid

mp

178-180 °C (lit.)

SMILES string

OC(=O)c1cncc(Br)c1

InChI

1S/C6H4BrNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,(H,9,10)

InChI key

FQIUCPGDKPXSLL-UHFFFAOYSA-N

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应用

5-溴吡啶-3-羧酸(5-溴烟酸)用于合成3-胍基甲基-5-碘吡啶

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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G Vaidyanathan et al.
Bioconjugate chemistry, 9(6), 758-764 (1998-11-17)
Substituting a pyridine ring for a benzene ring in the acylation agent N-succinimidyl 3-iodobenzoate has resulted in a useful approach for the radiohalogenation of monoclonal antibodies, peptides, and labeled biotin conjugates. It was hypothesized that such a substitution in m-iodobenzylguanidine
F Gabor et al.
Journal of pharmaceutical sciences, 84(9), 1120-1125 (1995-09-01)
Two types of monoclonal antibodies were used for the determination of nicergoline in biological matrices. The antibodies were prepared with the hydrolysis products 5-bromonicotinic acid and 1-methyl-10 alpha-methoxydihydrolysergol after hemisuccinoylation to haptens. The current amide bond-generating methods (mixed anhydride-, carbodiimide-
Małgorzata Dukat et al.
European journal of pharmacology, 435(2-3), 171-180 (2002-02-01)
Two 5-substituted derivatives of nicotine (nicotinic acetylcholine receptor: K(i)=2.4 nM) were synthesized and evaluated: 5-bromonicotine (K(i)=6.9 nM) and 5-methoxynicotine (K(i)=14.3 nM). Despite their high affinity, neither 5-bromonicotine nor 5-methoxynicotine mimicked nicotine in producing antinociceptive (tail-flick, hotplate), hypolocomotor, or hypothermic effects
Tawfik Gharbaoui et al.
Bioorganic & medicinal chemistry letters, 17(17), 4914-4919 (2007-06-26)
A strategy for lead identification of new agonists of GPR109a, starting from known compounds shown to activate the receptor, is described. Early compound triage led to the formulation of a binding hypothesis and eventually to our focus on a series

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