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228435

5-溴吡啶-3-羧酸

Name: 5-溴吡啶-3-羧酸
Brand: ALDRICH

98%

别名:

5-溴烟酸

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关于此项目

经验公式（希尔记法）:

C₆H₄BrNO₂

化学文摘社编号:

20826-04-4

分子量:

202.01

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24853685

EC Number:

244-065-5

Beilstein/REAXYS Number:

115854

MDL number:

MFCD00009783

Assay:

98%

Form:

solid

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属性

Quality Level

100

assay

98%

form

solid

mp

178-180 °C (lit.)

functional group

bromo, carboxylic acid

SMILES string

OC(=O)c1cncc(Br)c1

InChI

1S/C6H4BrNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,(H,9,10)

InChI key

FQIUCPGDKPXSLL-UHFFFAOYSA-N

说明

Application

5-溴吡啶-3-羧酸（5-溴烟酸）用于合成3-胍基甲基-5-碘吡啶。

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

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Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine.

G Vaidyanathan et al.

Bioconjugate chemistry, 9(6), 758-764 (1998-11-17)

Substituting a pyridine ring for a benzene ring in the acylation agent N-succinimidyl 3-iodobenzoate has resulted in a useful approach for the radiohalogenation of monoclonal antibodies, peptides, and labeled biotin conjugates. It was hypothesized that such a substitution in m-iodobenzylguanidine

Functional diversity among 5-substituted nicotine analogs; in vitro and in vivo investigations.

Małgorzata Dukat et al.

European journal of pharmacology, 435(2-3), 171-180 (2002-02-01)

Two 5-substituted derivatives of nicotine (nicotinic acetylcholine receptor: K(i)=2.4 nM) were synthesized and evaluated: 5-bromonicotine (K(i)=6.9 nM) and 5-methoxynicotine (K(i)=14.3 nM). Despite their high affinity, neither 5-bromonicotine nor 5-methoxynicotine mimicked nicotine in producing antinociceptive (tail-flick, hotplate), hypolocomotor, or hypothermic effects

Drug-protein conjugates: haptenation of 1-methyl-10 alpha-methoxydihydrolysergol and 5-bromonicotinic acid to albumin for the production of epitope-specific monoclonal antibodies against nicergoline.

F Gabor et al.

Journal of pharmaceutical sciences, 84(9), 1120-1125 (1995-09-01)

Two types of monoclonal antibodies were used for the determination of nicergoline in biological matrices. The antibodies were prepared with the hydrolysis products 5-bromonicotinic acid and 1-methyl-10 alpha-methoxydihydrolysergol after hemisuccinoylation to haptens. The current amide bond-generating methods (mixed anhydride-, carbodiimide-

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全球贸易项目编号

货号	GTIN
228435-50G	04061832977393
228435-10G	04061838781208