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Merck
CN

247898

Sigma-Aldrich

异山梨醇二甲醚

98%

别名:

DMI, 二甲基异山梨醇, 1,4:3,6-二脱水-2,5-二-O-甲基-D-葡糖醇, 1,4:3,6-二脱水山梨醇 2,5-二甲醚, 2,5-二-O-甲基-1,4:3,6-二脱水-D-葡糖醇, 异山梨醇二甲醚

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关于此项目

经验公式(希尔记法):
C8H14O4
CAS Number:
分子量:
174.19
Beilstein:
80854
EC 号:
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
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质量水平

方案

98%

表单

liquid

旋光性

[α]21/D +96.1°, c = 2 in chloroform

折射率

n20/D 1.461 (lit.)

沸点

93-95 °C/0.1 mmHg (lit.)

密度

1.15 g/mL at 25 °C (lit.)

SMILES字符串

CO[C@H]1COC2[C@@H](COC12)OC

InChI

1S/C8H14O4/c1-9-5-3-11-8-6(10-2)4-12-7(5)8/h5-8H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1

InChI key

MEJYDZQQVZJMPP-ULAWRXDQSA-N

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应用

异山梨醇二甲醚(DMI)是一种可持续溶剂,广泛用于各种化妆品和药物配方中。
通用应用:
  • DMI 可用作环辛烯环氧化的替代绿色溶剂,异麦芽酮糖衍生醛与 α,β-不饱和酮的贝里斯-希尔曼反应,也可用于固相合成。
  • 它可以用作水性涂料的聚结剂,在失水阶段充当共溶剂,在成膜过程中充当聚结剂。

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

240.8 °F - closed cup

闪点(°C)

116 °C - closed cup

个人防护装备

Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 46(3), 265-271 (1999-01-14)
The in vitro percutaneous fluxes of propylene glycol (PG), cis-oleic acid (OA) and dimethyl isosorbide (DI) were determined and their effect on nifedipine (N) flux and lag time evaluated. PG, OA and DI flux through hairless mouse (HM) skin was
Greener solvents for solid-phase synthesis.
Lawrenson S, et al.
Green Chemistry, 19(4), 952-962 (2017)
Adrian P Funke et al.
Pharmaceutical research, 19(5), 661-668 (2002-06-19)
Highly lipophilic basic drugs, the antiestrogens AE 1 (log P = 5.82) and AE 2 (log P = 7.8) shall be delivered transdermally. Transdermal permeation of drugs, enhancers, and solvents from various fluid formulations were characterized by in-vitro permeation studies
M Brisaert et al.
Pharmacy world & science : PWS, 18(5), 182-186 (1996-10-01)
Erythromycin, an antibiotic commonly used topically in the treatment of acne, is unstable in solution. The stability is influenced by the pH and by the presence of water. The influence of the pH on the stability of erythromycin was investigated
Y Zhang et al.
International journal of cosmetic science, 41(5), 479-488 (2019-08-06)
Phenylethyl resorcinol (PR) has been used widely in the personal care industry as a novel skin lightening ingredient. Surprisingly, there is only limited information describing the physicochemical properties of this active. Therefore, the primary objective of this study was to

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