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经验公式(希尔记法):
C2H3N3S
化学文摘社编号:
分子量:
101.13
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
223-657-7
Beilstein/REAXYS Number:
107135
MDL number:
Assay:
97%
Form:
powder
InChI key
QUKGLNCXGVWCJX-UHFFFAOYSA-N
InChI
1S/C2H3N3S/c3-2-5-4-1-6-2/h1H,(H2,3,5)
SMILES string
Nc1nncs1
assay
97%
form
powder
mp
188-191 °C (dec.) (lit.)
solubility
water: soluble 25 mg/mL, clear, colorless
Quality Level
General description
2-氨基-1,3,4-噻二唑(供体)与 2,3-二氯-5,6-二氰--p -苯醌、-p -氯醌、-o -氯醌、-p -溴苯腈和氯苯胺酸(受体)形成电荷转移络合物 。2-氨基-1,3,4-噻二唑 [氨基噻二唑 (NSC 4728)] 对体内 L1210 腹水细胞 的嘌呤和嘧啶核苷酸池的影响 已有报道 。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
M Gaber et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 62(1-3), 526-531 (2005-11-01)
Charge transfer (CT) complexes formed between 2-amino-1,3,4-thiadiazole as donor and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), p-chloranil (p-CHL), o-chloranil (o-CHL), p-bromanil (BRL) and chloranilic acid (CHA) as acceptors, have been studied spectrophotometrically. Benesi-Hildebrand and Job continuous variation methods were applied to the determination of
G Mazzone et al.
Farmaco (Societa chimica italiana : 1989), 48(9), 1207-1224 (1993-09-01)
We prepared some series of 2-(alkylaminoacyl) derivatives of 2-amino-1,3,4-thiadiazoles. Most terms were subjected to a biological screening showing a local anesthetic activity both in infiltration and trunkular tests. For some of the assayed derivatives, the activity was comparable to that
P J Elson et al.
Investigational new drugs, 6(2), 97-103 (1988-06-01)
One hundred and forty-four evaluable patients with recurrent or metastatic renal cell carcinoma (RCC) were treated with vinblastine infusion (n = 35), L-alanosine (n = 36), acivicin (n = 27), or aminothiadiazole (n = 46). Observed objective response rates of
R F Asbury et al.
American journal of clinical oncology, 12(5), 375-377 (1989-10-01)
Twenty-six evaluable patients with advanced nonsquamous cell cervical cancer were treated with aminothiadiazole at a dosage of 125 mg/m2 weekly. Sixteen had received prior chemotherapy. Two patients had complete responses neither had received prior chemotherapy; nine had stable disease; 15
M Juszczak et al.
Bioorganic & medicinal chemistry letters, 22(17), 5466-5469 (2012-08-11)
The anticancer potential of 2-amino-1,3,4-thiadiazole compounds has been documented by in vitro and in vivo studies. In our previous research, we described the synthesis as well as the antiproliferative and neuroprotective activities of 2-(4-fluorophenyloamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole (FABT). The aim of the present
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