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经验公式(希尔记法):
C2H3N3S
化学文摘社编号:
分子量:
101.13
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
223-657-7
Beilstein/REAXYS Number:
107135
MDL number:
产品名称
2-氨基-1,3,4-噻二唑, 97%
InChI key
QUKGLNCXGVWCJX-UHFFFAOYSA-N
InChI
1S/C2H3N3S/c3-2-5-4-1-6-2/h1H,(H2,3,5)
SMILES string
Nc1nncs1
assay
97%
form
powder
mp
188-191 °C (dec.) (lit.)
solubility
water: soluble 25 mg/mL, clear, colorless
Quality Level
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General description
2-氨基-1,3,4-噻二唑(供体)与 2,3-二氯-5,6-二氰--p -苯醌、-p -氯醌、-o -氯醌、-p -溴苯腈和氯苯胺酸(受体)形成电荷转移络合物 。2-氨基-1,3,4-噻二唑 [氨基噻二唑 (NSC 4728)] 对体内 L1210 腹水细胞 的嘌呤和嘧啶核苷酸池的影响 已有报道 。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
R F Asbury et al.
American journal of clinical oncology, 13(1), 39-41 (1990-02-01)
Twenty-one evaluable patients with advanced carcinoma of the endometrium were treated with aminothiadiazole at a dosage of 125 mg/m2 weekly. Twelve had received prior chemotherapy. Seven patients had stable disease; 14 had increasing disease. There were two life-threatening toxic episodes.
Palraj Kalimuthu et al.
Talanta, 80(5), 1686-1691 (2010-02-16)
This paper describes the simultaneous determination of ascorbic acid (AA), dopamine (DA), uric acid (UA) and xanthine (XN) using an ultrathin electropolymerized film of 2-amino-1,3,4-thiadiazole (p-ATD) modified glassy carbon (GC) electrode in 0.20 M phosphate buffer solution (pH 5.0). Bare
R F Asbury et al.
American journal of clinical oncology, 10(5), 380-382 (1987-10-01)
The Eastern Cooperative Oncology Group (ECOG) studied 29 patients with advanced measurable colon cancer who were treated with Aminothiadiazole (NSC #4728) 125 mg/m2 intravenously. Allopurinol 300 mg daily was taken by all patients during treatment. Three patients (12%) demonstrated partial
Małgorzata Juszczak et al.
Folia histochemica et cytobiologica, 49(3), 436-444 (2011-11-01)
The 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole set are well known compounds with interesting in vitro and in vivo anti-cancer profiles. The aim of this study was an in vitro evaluation of the anti-cancer activity of a new synthesized aminothiadiazole derivative 2-(3-chlorophenyloamino)-5-(2,4-dihydroxyphenyl)- -1,3,4-thiadiazole 4ClABT. The
M Juszczak et al.
Bioorganic & medicinal chemistry letters, 22(17), 5466-5469 (2012-08-11)
The anticancer potential of 2-amino-1,3,4-thiadiazole compounds has been documented by in vitro and in vivo studies. In our previous research, we described the synthesis as well as the antiproliferative and neuroprotective activities of 2-(4-fluorophenyloamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole (FABT). The aim of the present
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