264423
2,5-二氟苄基溴
98%
别名:
α-溴-2,5-二氟甲苯
方案
98%
折射率
n20/D 1.526 (lit.)
密度
1.609 g/mL at 25 °C (lit.)
官能团
bromo
fluoro
SMILES字符串
Fc1ccc(F)c(CBr)c1
InChI
1S/C7H5BrF2/c8-4-5-3-6(9)1-2-7(5)10/h1-3H,4H2
InChI key
ONWGSWNHQZYCFK-UHFFFAOYSA-N
应用
2,5-Difluorobenzyl bromide has been used in the synthesis of:
- novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors, for the potential treatment of Alzheimer′s disease
- sulfonamide, amide and acyclic amine derivatives
警示用语：
Danger
危险声明
危险分类
Flam. Liq. 2 - Skin Corr. 1B
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
60.8 °F - closed cup
闪点(°C)
16 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
新产品
Martin Teall et al.
Bioorganic & medicinal chemistry letters, 15(10), 2685-2688 (2005-05-03)
The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
Ping Chen et al.
Bioorganic & medicinal chemistry letters, 21(6), 1880-1886 (2011-02-16)
A series of 4-amino cyclohexanes and 4-substituted piperidines were prepared and evaluated for inhibition of DPP-4. Analog 20q displayed both good DPP-4 potency and selectivity against other proteases, while derivative 20k displayed long half life and modest oral bioavailability in
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