268542
甲基丙烯酸羟丙酯
Mixture of hydroxypropyl and hydroxyisopropyl methacrylates, 97%, contains 180-220 ppm monomethyl ether hydroquinone as inhibitor
别名:
HPMA
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关于此项目
化学文摘社编号:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
Beilstein/REAXYS Number:
1752228
SMILES string
CC(=C)C(=O)OCCCO
InChI
1S/C7H12O3/c1-5(2)7(9)10-6(3)4-8/h6,8H,1,4H2,2-3H3
InChI key
ZMARGGQEAJXRFP-UHFFFAOYSA-N
vapor density
>1 (vs air)
vapor pressure
0.05 mmHg ( 20 °C)
assay
97%
form
liquid
contains
180-220 ppm monomethyl ether hydroquinone as inhibitor
refractive index
n20/D 1.447 (lit.)
bp
57 °C/0.5 mmHg (lit.)
density
1.066 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Quality Level
Application
- 掺入Zn/Ce取代的羟基磷灰石纳米粒子的聚羟丙基甲基丙烯酸酯冰胶的合成，用于股骨骨折的修复：这项研究探索了掺入羟丙基甲基丙烯酸酯和Zn/Ce取代的羟基磷灰石纳米粒子的冰胶的合成，旨在用于骨骨折愈合（H Zhou，H Jiao，J Xu，Y Liu，S Wei，2019年）。
- 聚（羟丙基甲基丙烯酸酯-共-缩水甘油基甲基丙烯酸酯）：含有羟基官能甲基丙烯酸酯的明确疏水性凝胶的简便合成：本文介绍了使用羟丙基甲基丙烯酸酯和缩水甘油基甲基丙烯酸酯合成疏水性凝胶的方法，这些凝胶可用于各种材料应用（N Orakdogen，B Sanay，2017年）。
- 聚（羟丙基甲基丙烯酸酯）薄膜的引发化学气相沉积：该研究涵盖了在膜上创建聚（羟丙基甲基丙烯酸酯）薄膜的化学气相沉积过程，增强了其功能特性（E Sevgili，M Karaman，2019年）。
signalword
Danger
Hazard Classifications
Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
203.0 °F - closed cup
flash_point_c
95 °C - closed cup
Annette Kelsch et al.
Biomacromolecules, 13(12), 4179-4187 (2012-11-28)
In this work we describe the application of amphiphilic N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers as polymeric surfactants in miniemulsion techniques. HPMA-based copolymers with different ratios of HPMA (hydrophilic) to laurylmethacrylate (LMA; hydrophobic) units were synthesized by RAFT polymerization and postpolymerization modification. The
Yang Yang et al.
Biomaterials, 33(7), 2260-2271 (2011-12-23)
Galectin-3 (Gal-3), over-expressed on a variety of human tumor cells, is a potential binding site for targeted metastatic prostate cancer therapy. The aim of this study was to develop a G3-C12-mediated drug delivery system based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers
Adam J Gormley et al.
Journal of controlled release : official journal of the Controlled Release Society, 166(2), 130-138 (2012-12-25)
Effective drug delivery to tumors requires both transport through the vasculature and tumor interstitium. Previously, it was shown that gold nanorod (GNR) mediated plasmonic photothermal therapy (PPTT) is capable of increasing the overall accumulation of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers in prostate
Stefan Hoffmann et al.
Biomacromolecules, 13(3), 652-663 (2012-01-24)
Preclinical in vivo characterization of new polymeric drug conjugate candidates is crucial for understanding the effects of certain chemical modifications on distribution and elimination of these carrier systems, which is the basis for rational drug design. In our study we
Russell N Johnson et al.
Biomacromolecules, 13(3), 727-735 (2012-02-01)
High-molecular-weight, branched N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesized and conjugated with Fab' fragments of the anti-CD20 antibody, 1F5. This produced multivalent conjugates with varying valency (amount of Fab' per macromolecule) targeted to the B-cell antigen CD20. The apoptotic activity of the
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