产品名称
1-氰基-1-环丙烷羧酸, 97%
InChI
1S/C5H5NO2/c6-3-5(1-2-5)4(7)8/h1-2H2,(H,7,8)
SMILES string
OC(=O)C1(CC1)C#N
InChI key
KSJJMSKNZVXAND-UHFFFAOYSA-N
assay
97%
mp
140 °C (lit.)
functional group
carboxylic acid
nitrile
Quality Level
Application
1-Cyano-1-cyclopropanecarboxylic acid may be used in the synthesis of amidine-based nanomolar sphingosine kinase1 subtype-selective inhibitors.
General description
1-Cyano-1-cyclopropanecarboxylic acid (1-Cyanocyclopropanecarboxylic acid) is a substituted cyclopropane. It is the intermediate formed during homoconjugate addition of nucleophiles to cyclopropane-1,1-dicarboxylate derivative.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Substituted cyclopropanes. 5. 1-Cyanocyclopropanecarboxylic acid.
Jones PG and Schrumpf G.
Acta Crystallographica Section C, Structural Chemistry, 43(8), 1576-1579 (1987)
Homoconjugate Addition of Nucleophiles to Cyclopropane-1, 1-Dicarboxylate Derivatives: 2-Oxo-1-Phenyl-3-Pyrrolidinecarboxylic Acid.
Singh RK and Danishefsky S.
Organic Syntheses, 66-66 null
Andrew J Kennedy et al.
Journal of medicinal chemistry, 54(10), 3524-3548 (2011-04-19)
Sphingosine 1-phosphate (S1P) is a bioactive lipid that has been identified as an accelerant of cancer progression. The sphingosine kinases (SphKs) are the sole producers of S1P, and thus, SphK inhibitors may prove effective in cancer mitigation and chemosensitization. Of
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