Merck
CN

347795

Sigma-Aldrich

二氯乙酸钠

98%

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别名:
二氯乙酸 钠盐
线性分子式:
Cl2CHCO2Na
CAS号:
分子量:
150.92
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

检测方案

98%

杂质

<2% ethyl alcohol

mp

198 °C (dec.) (lit.)

SMILES string

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

InChI key

LUPNKHXLFSSUGS-UHFFFAOYSA-M

Gene Information

相关类别

一般描述

二氯乙酸钠是一种线粒体丙酮酸脱氢酶激酶(PDK)抑制剂,具有强大的抗白血病活性。

应用

二氯乙酸钠可用作合成微孔碳的有机盐前体,其可用于开发碳基吸附剂。

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险分类

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. I have heard that dichloroacetate has been used for cancer treatment.  Is Product 347795, Sodium dichloroacetate, the same chemical?

    Some research studies on the use of dichloroacetate as an anti-cancer agent have been performed.  At this time, no dichloroacetate compound or product has been approved for use as an anti-cancer drug.  The common salts of dichloroacetate are sodium and potassium, and these are what have been used in the research studies.  The Sigma-Aldrich products 347795, Sodium Dichloroacetate, and 348082, Potassium Dichloroacetate, are offered for laboratory use only, and are not manufactured or intended for human use.

  4. How can I make a solution of Product 347795, Sodium dichloroacetate?

    Sodium dichloroacetate is soluble in water at 50 mg/ml.

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Yongchong Yang et al.
European journal of medicinal chemistry, 45(9), 4300-4306 (2010-07-29)
A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC(50) > 1000 microM for A549). In this paper, a variety of DCA derivatives were synthesized, and
Peng Wang et al.
Shock (Augusta, Ga.), 49(6), 704-711 (2017-08-29)
No pharmacological interventions are currently available to provide neuroprotection for patients suffering from cardiac arrest. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase inhibitor, which activates pyruvate dehydrogenase (PDH), and increases cell adenosine triphosphate (ATP) production by promoting influx of pyruvate
Case report: sodium dichloroacetate (DCA) inhibition of the ?Warburg Effect? in a human cancer patient: complete response in non-Hodgkin?s lymphoma after disease progression with rituximab-CHOP.
Strum SB., et al.
Journal of Bioenergetics and Biomembranes, 45(3), 307-315 (2013)
Roald A Lambrechts et al.
EMBO molecular medicine, 11(12), e10488-e10488 (2019-11-09)
PKAN, CoPAN, MePAN, and PDH-E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA biosynthesis (PKAN, CoPAN), protein lipoylation
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to

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We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.

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