Merck
CN

349119

Sigma-Aldrich

1-苯基靛红

97%

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别名:
1-Phenyl-2,3-indolinedione, NSC 100013
经验公式(希尔记法):
C14H9NO2
CAS号:
分子量:
223.23
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

检测方案

97%

mp

138-140 °C (lit.)

SMILES string

O=C1N(c2ccccc2)c3ccccc3C1=O

InChI

1S/C14H9NO2/c16-13-11-8-4-5-9-12(11)15(14(13)17)10-6-2-1-3-7-10/h1-9H

InChI key

UWCPWBIMRYXUOU-UHFFFAOYSA-N

一般描述

1-Phenylisatin is an isatin. It is a potential anticancer, anti-HIV drug. Its binding interaction with a model transport protein bovine serum albumin (BSA) has been investigated using fluorescence spectroscopic technique. Interactions between human adult hemoglobin (Hb) and 1-phenylisatin has been investigated by steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR and anisotropy.

应用

Reactant for preparation of:
  • Indolin-2,3-dione Schiff bases as potential antimycobacterial agents
  • Antipyretic agents
  • Antiproliferative agents
  • Selective Cannabinoid Receptor 2 Agonists for the Treatment of Neuropathic Pain
  • Phenylacetamides as anticonvulsant agents
  • Selective Galanin GAL3 Receptor Antagonists

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Acute Tox. 4 Oral

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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Bijan Kumar Paul et al.
Physical chemistry chemical physics : PCCP, 15(4), 1275-1287 (2012-12-13)
The present contribution reports a detailed characterization of the binding interaction of a potential anticancer, anti-HIV drug 1-phenylisatin (1-PI) with a model transport protein Bovine Serum Albumin (BSA) using fluorescence spectroscopic techniques. The thermodynamic parameters e.g., ΔH, ΔS and ΔG
Puspita Sahu et al.
Psychopharmacology, 236(6), 1829-1838 (2019-01-23)
Cannabinoid receptor 2 (CB2R) signaling in the brain is associated with the pathophysiology of depression. Sickness behavior, characterized by lessened mobility, social interaction, and depressive behavior, is linked with neuroinflammation, oxidative stress, and immune system. The present study was aimed
Paulami Mandal et al.
The journal of physical chemistry. B, 113(45), 14904-14913 (2009-10-13)
In this report, steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR, and anisotropy investigations were made to reveal the nature of the interactions between human adult hemoglobin (Hb) and the isatins, 1-methylisatin (1-MI) and 1-phenylisatin (1-PI).

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