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Merck
CN

349119

1-苯基靛红

97%

别名:

1-Phenyl-2,3-indolinedione, NSC 100013

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关于此项目

经验公式(希尔记法):
C14H9NO2
化学文摘社编号:
分子量:
223.23
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
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产品名称

1-苯基靛红, 97%

InChI

1S/C14H9NO2/c16-13-11-8-4-5-9-12(11)15(14(13)17)10-6-2-1-3-7-10/h1-9H

SMILES string

O=C1N(c2ccccc2)c3ccccc3C1=O

InChI key

UWCPWBIMRYXUOU-UHFFFAOYSA-N

assay

97%

mp

138-140 °C (lit.)

functional group

ketone

Application

Reactant for preparation of:
  • Indolin-2,3-dione Schiff bases as potential antimycobacterial agents
  • Antipyretic agents
  • Antiproliferative agents
  • Selective Cannabinoid Receptor 2 Agonists for the Treatment of Neuropathic Pain
  • Phenylacetamides as anticonvulsant agents
  • Selective Galanin GAL3 Receptor Antagonists

General description

1-Phenylisatin is an isatin. It is a potential anticancer, anti-HIV drug. Its binding interaction with a model transport protein bovine serum albumin (BSA) has been investigated using fluorescence spectroscopic technique. Interactions between human adult hemoglobin (Hb) and 1-phenylisatin has been investigated by steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR and anisotropy.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Bijan Kumar Paul et al.
Physical chemistry chemical physics : PCCP, 15(4), 1275-1287 (2012-12-13)
The present contribution reports a detailed characterization of the binding interaction of a potential anticancer, anti-HIV drug 1-phenylisatin (1-PI) with a model transport protein Bovine Serum Albumin (BSA) using fluorescence spectroscopic techniques. The thermodynamic parameters e.g., ΔH, ΔS and ΔG
Puspita Sahu et al.
Psychopharmacology, 236(6), 1829-1838 (2019-01-23)
Cannabinoid receptor 2 (CB2R) signaling in the brain is associated with the pathophysiology of depression. Sickness behavior, characterized by lessened mobility, social interaction, and depressive behavior, is linked with neuroinflammation, oxidative stress, and immune system. The present study was aimed
Paulami Mandal et al.
The journal of physical chemistry. B, 113(45), 14904-14913 (2009-10-13)
In this report, steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR, and anisotropy investigations were made to reveal the nature of the interactions between human adult hemoglobin (Hb) and the isatins, 1-methylisatin (1-MI) and 1-phenylisatin (1-PI).

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