379409
1,2-二甲基-3-羟基-4-吡啶酮
98%
别名:
去铁酮
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关于此项目
经验公式（希尔记法）:
C7H9NO2
化学文摘社编号:
分子量:
139.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
98%
Form:
powder
InChI
1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
SMILES string
CN1C=CC(=O)C(O)=C1C
InChI key
TZXKOCQBRNJULO-UHFFFAOYSA-N
assay
98%
form
powder
mp
272-275 °C (lit.)
functional group
ketone
Quality Level
General description
3-羟基-1,2-二甲基-4(1H)-吡啶酮（Hdpp，去铁酮）是一种羟基酮衍生物。 它在酸性水溶液中与铀酰盐[UO2(NO3)2]反应，得到单核复合物（[UO2(dpp)(Hdpp)2(H2O)]ClO4）。 已通过X射线研究分析了这些复合物的结构和几何结构。
Application
3-羟基-1,2-二甲基-4(1H)-吡啶酮（OH-吡啶酮）可用于杀菌试验。它已被用作羟基酮螯合剂，并且已经评估了其对人口腔正常和肿瘤细胞的细胞毒作用。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Inflammatory diseases associated with iron overload are characterized by a changed coagulation profile, where there is a persistent presence of fibrin-like material of dense-matted deposits (DMDs). It is believed that one source of such material is a result of the
Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines.
Eiji Yasumoto et al.
Anticancer research, 24(2B), 755-762 (2004-05-27)
Hydroxyketone chelators, deferiprone (HK1), maltol (HK3) and their related compounds (HK2, 4-8), were characterized for their cytotoxic profiles against oral human normal and tumor cells. Most hydroxyketones except HK6 showed relatively higher tumor-specific cytotoxicity. Deferiprone (HK1), which showed the highest
Chryssoula Drouza et al.
Inorganic chemistry, 43(26), 8336-8345 (2004-12-21)
Reaction of [UO(2)(NO(3))(2)] with the hydroxy ketones 3-hydroxy-2-methyl-4-pyrone (Hma) and 3-hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp) in aqueous acidic solutions (pH approximately 3) yields the compounds [UO(2)(ma)(2)(H(2)O)].H(2)O (1.H(2)O) and [UO(2)(dpp)(Hdpp)(2)(H(2)O)]ClO(4) (2), respectively. X-ray diffraction shows that the geometry around the metal ion in both
Matthew R Bedford et al.
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Iron plays a crucial role in a number of metabolic pathways including oxygen transport, DNA synthesis, and ATP generation. Although insufficient systemic iron can result in physical impairment, excess iron has also been implicated in a number of diseases including
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