产品名称
(R)-3-吡咯烷醇, 98%
InChI
1S/C4H9NO/c6-4-1-2-5-3-4/h4-6H,1-3H2/t4-/m1/s1
SMILES string
O[C@@H]1CCNC1
InChI key
JHHZLHWJQPUNKB-SCSAIBSYSA-N
assay
98%
optical activity
[α]20/D +6.5°, c = 3.5 in methanol
impurities
<2% tetraethylene glycol dimethyl ether
refractive index
n20/D 1.488 (lit.)
bp
215-216 °C (lit.)
density
1.078 g/mL at 20 °C (lit.)
functional group
hydroxyl
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Application
用作二乙基锌不对称加成至芳醛以生成光学活性仲醇的配体。还用于制备 κ-阿片受体激动剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Mehler, T. et al.
Synthetic Communications, 23, 2691-2691 (1993)
A Naylor et al.
Journal of medicinal chemistry, 37(14), 2138-2144 (1994-07-08)
The synthesis of 5-(arylacetyl)-4-[(alkylamino)methyl]furo[3,2-c] pyridines (16-23, 26, 27) and their activities as kappa-opioid receptor agonists are described. kappa-Agonist potency was particularly sensitive to the nature of the basic moiety. In particular, in the rabbit vas deferens (kappa-specific tissue), the 3-pyrrolidinol
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