389439
1-芘甲醇
98%
别名:
1-羟甲基芘, 1-（1-羟甲基）芘
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关于此项目
经验公式（希尔记法）:
C17H12O
化学文摘社编号:
分子量:
232.28
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
98%
表单
solid
mp
123-126 °C (lit.)
官能团
hydroxyl
SMILES字符串
OCc1ccc2ccc3cccc4ccc1c2c34
InChI
1S/C17H12O/c18-10-14-7-6-13-5-4-11-2-1-3-12-8-9-15(14)17(13)16(11)12/h1-9,18H,10H2
InChI key
NGDMLQSGYUCLDC-UHFFFAOYSA-N
应用
1-芘乙醇可用于：
- 合成腺苷-5′ 的钳形苯桥接荧光选择性传感器-三磷酸盐 (ATP) 检测。
- 作为合成芘端聚甲基丙烯酸缩水甘油酯聚合物的起始原料。
- 作为合成芘核心星形聚合物的引发剂。
- 合成医药和农药领域的重要中间体 1-芘甲醛。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Bernhard H Monien et al.
Toxicology, 262(1), 80-85 (2009-06-02)
1-Methylpyrene (1-MP), an abundant alkylated polycyclic aromatic hydrocarbon, is activated by side-chain hydroxylation to 1-hydroxymethylpyrene (1-HMP) and subsequent sulfo-conjugation to electrophilic 1-sulfooxymethylpyrene (1-SMP). In rats, this activation mainly occurs in liver. 1-SMP may react with hepatic DNA or be exported
Ronny Kollock et al.
Biochemical pharmacology, 75(2), 527-537 (2007-10-09)
Alkylated polycyclic aromatic hydrocarbons can be metabolically activated via benzylic hydroxylation and sulphation to electrophilically reactive esters. However, we previously found that the predominant biotransformation route for the hepatocarcinogen 1-hydroxymethylpyrene (1-HMP) in the rat in vivo is the oxidation of
C D Sherman et al.
Carcinogenesis, 16(10), 2499-2506 (1995-10-01)
The promotional effect of phenobarbital and 1-hydroxymethyl-pyren on enzyme altered lesions in the rat liver were quantified within the framework of two separate multipath/multistage models. The experiment analyzed followed an initiation-promotion protocol in which female Wistar rats were initiated with
H Glatt et al.
Environmental health perspectives, 88, 43-48 (1990-08-01)
Methylated polycyclic aromatic hydrocarbons are common in the human environment. Many of them are stronger carcinogens than their purely aromatic congeners. They may be metabolized to benzylic alcohols. We report here on biochemical and toxicological characteristics of 1-hydroxymethylpyrene (HMP), a
Thermal conductivity and structure of non-covalent functionalized graphene/epoxy composites.
Teng CC, et al.
Carbon, 49(15), 5107-5116 (2011)
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