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421626

(S)-1,2,3,4-四氢-3-异喹啉羧酸

Name: (<I>S</I>)-1,2,3,4-四氢-3-异喹啉羧酸
Brand: ALDRICH

97%

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₁NO₂

化学文摘社编号:

74163-81-8

分子量:

177.20

UNSPSC Code:

12352106

NACRES:

NA.22

PubChem Substance ID:

24866388

MDL number:

MFCD00144533

Beilstein/REAXYS Number:

4842199

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属性

Quality Level

100

assay

97%

form

solid

optical activity

[α]20/D −168°, c = 1.8 in 1.4 M NaOH

reaction suitability

reaction type: solution phase peptide synthesis

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

OC(=O)[C@@H]1Cc2ccccc2CN1

InChI

1S/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)/t9-/m0/s1

InChI key

BWKMGYQJPOAASG-VIFPVBQESA-N

说明

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport.

Bradford H Hirth et al.

Bioorganic & medicinal chemistry letters, 15(8), 2087-2091 (2005-04-06)

A series of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase chloride transport in cells expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein has been identified from our compound library. Analoging efforts and the resulting structure-activity relationships uncovered are detailed. Compound potency

pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy.

Li Li et al.

Nanomedicine : nanotechnology, biology, and medicine, 8(7), 1216-1222 (2012-01-18)

The modification of 3S-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA) with β-cyclodextrin (β-CD) provides an oral antithrombotic agent, 6-(3'S-isoquinoline-3'-carboxylaminoethylamino)-6-deoxy-β-CD (THIQA-β-CD). In aqueous solution THIQA-β-CD undergoes intermolecular inclusion complexation and forms pH-dependent nanostructures. The morphological feature of THIQA-β-CD is a nanocloud consisting of numerous particles

Rational design of dynorphin A analogues with delta-receptor selectivity and antagonism for delta- and kappa-receptors.

R Guerrini et al.

Bioorganic & medicinal chemistry, 6(1), 57-62 (1998-03-21)

Substitution of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) in place of Gly2 in dynorphin A-(1-13)-NH2 and -(1-11)-NH2 (DYN) analogues (1 and 2) decreased the affinity to the kappa, delta, and mu receptors, and kappa selectivity. The analogue [D-Ala2, des-Gly3]DYN (4), a chimera between

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货号	GTIN
421626-5G	04061832093956