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Merck
CN

535893

5-甲基尿苷

97%

别名:

胸腺嘧啶核糖核苷

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关于此项目

经验公式(希尔记法):
C10H14N2O6
化学文摘社编号:
分子量:
258.23
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
215-973-9
MDL number:
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产品名称

5-甲基尿苷, 97%

InChI key

DWRXFEITVBNRMK-JXOAFFINSA-N

InChI

1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1

SMILES string

CC1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(=O)NC1=O

assay

97%

mp

183-184 °C (lit.)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

Lot/Batch Number

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H F Becker et al.
Journal of molecular biology, 274(4), 505-518 (1998-01-07)
Almost all transfer RNA molecules sequenced so far contain two universal modified nucleosides at positions 54 and 55, respectively: ribothymidine (T54) and pseudouridine (psi 55). To identify the tRNA elements recognized by tRNA:m5uridine-54 methyltransferase and tRNA:pseudouridine-55 synthase from the yeast
Benoit Desmolaize et al.
Nucleic acids research, 39(21), 9368-9375 (2011-08-10)
Methyltransferases that use S-adenosylmethionine (AdoMet) as a cofactor to catalyse 5-methyl uridine (m(5)U) formation in tRNAs and rRNAs are widespread in Bacteria and Eukaryota, and are also found in certain Archaea. These enzymes belong to the COG2265 cluster, and the
Ya-Ming Hou et al.
FEBS letters, 584(2), 278-286 (2009-12-01)
Methylation of tRNA on the four canonical bases adds structural complexity to the molecule, and improves decoding specificity and efficiency. While many tRNA methylases are known, detailed insight into the catalytic mechanism is only available in a few cases. Of
Sanjay Agarwalla et al.
The Journal of biological chemistry, 277(11), 8835-8840 (2002-01-10)
An Escherichia coli open reading frame, ygcA, was identified as a putative 23 S ribosomal RNA 5-methyluridine methyltransferase (Gustafsson, C., Reid, R., Greene, P. J., and Santi, D. V. (1996) Nucleic Acids Res. 24, 3756-3762). We have cloned, expressed, and
S Wang et al.
Bioorganic & medicinal chemistry, 5(6), 1043-1050 (1997-06-01)
In DNA triple helices, methylation at C-5 of thymine or cytosine is reported to have similar stabilizing effects for both bases. Here we show, however, that methylation of the same positions in RNA triplexes has distinctly different effects than in

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