542091
(S)-(-)-1-Boc-2-吡咯烷甲腈
97%
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关于此项目
经验公式（希尔记法）:
C10H16N2O2
化学文摘社编号:
分子量:
196.25
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
产品名称
(S)-(-)-1-Boc-2-吡咯烷甲腈, 97%
InChI
1S/C10H16N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(12)7-11/h8H,4-6H2,1-3H3/t8-/m0/s1
SMILES string
CC(C)(C)OC(=O)N1CCC[C@H]1C#N
InChI key
MDMSZBHMBCNYNO-QMMMGPOBSA-N
assay
97%
optical activity
[α]20/D −105.5°, c = 1 in chloroform
mp
33-36 °C (lit.)
Application
用于合成脯氨酰寡肽酶抑制剂。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Janice Lawandi et al.
Journal of medicinal chemistry, 52(21), 6672-6684 (2009-11-06)
Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program fitted, we have designed a series of constrained covalent inhibitors, built from
Erik A A Wallén et al.
Journal of medicinal chemistry, 46(21), 4543-4551 (2003-10-03)
Isophthalic acid bis(l-prolyl-pyrrolidine) amide is a very potent prolyl oligopeptidase inhibitor, but it has a log P value of -0.2, which is very low for a compound targeted to the brain. Therefore, these types of compounds were further modified to
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