637513
(S)-(+)-3-氟吡咯烷盐酸盐
97%
别名:
(3S)-(+)-3-Fluoropyrrolidine hydrochloride, (3S)-3-Fluoropyrrolidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C4H8FN · HCl
化学文摘社编号:
分子量:
125.57
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Assay:
97%
Form:
solid
InChI
1S/C4H8FN.ClH/c5-4-1-2-6-3-4;/h4,6H,1-3H2;1H/t4-;/m0./s1
SMILES string
Cl.F[C@H]1CCNC1
InChI key
LENYOXXELREKGZ-WCCKRBBISA-N
assay
97%
form
solid
optical activity
[α]20/D +8°, c = 1% in methanol
mp
183-187 °C (lit.)
functional group
fluoro
Quality Level
Application
(S)-(+)-3-Fluoropyrrolidine hydrochloride can be employed as a building block for the preparation of:
- Fluorinated pyrrolidine derivatives of cyclohexylglycine amides as potential inhibitors for dipeptidyl peptidase IV.
- Fluoropyrrolidine contaning N--ethylurea pyrazole derivatives as potential and selective inhibitors for Trypanosoma brucei and Trypanosoma cruzi parasitic causative agents.
- Urea derivatives of (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole as potent antitrypanosomal agents.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi
Varghese S, et al.
ACS Medicinal Chemistry Letters (2019)
Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors
Caldwell CG, et al.
Bioorganic & Medicinal Chemistry Letters, 14(5), 1265-1268 (2004)
Urea derivatives of 2-aryl-benzothiazol-5-amines: a new class of potential drugs for human African trypanosomiasis
Patrick DA, et al.
Journal of Medicinal Chemistry, 60(3), 957-971 (2017)
Charles G Caldwell et al.
Bioorganic & medicinal chemistry letters, 14(5), 1265-1268 (2004-02-26)
Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogues have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogues which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Compound 48 had good
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