64046
2,3-二巯基-1-丙醇
≥98% (iodometric)
别名:
BAL, DMP, 二巯丙醇, 二硫代甘油, 英国抗路易气剂
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关于此项目
线性分子式:
HOCH2CH(SH)CH2SH
化学文摘社编号:
分子量:
124.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-433-7
Beilstein/REAXYS Number:
1732058
MDL number:
Assay:
≥98% (iodometric)
产品名称
2,3-二巯基-1-丙醇, ≥98% (iodometric)
InChI key
WQABCVAJNWAXTE-UHFFFAOYSA-N
InChI
1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2
SMILES string
OCC(S)CS
assay
≥98% (iodometric)
refractive index
n20/D 1.572-1.574
n20/D 1.573 (lit.)
bp
120 °C/15 mmHg (lit.)
density
1.239 g/mL at 25 °C (lit.)
functional group
hydroxyl
thiol
storage temp.
2-8°C
Quality Level
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Application
2,3-二巯基-1-丙醇已用于合成新型(2-取代苯基-1,3-二硫杂环戊烷-4-基)甲醇（PDTM）衍生物，它们是有效的酪氨酸酶抑制剂。 由于它能够抑制HIV-1 tat活性，因此，它被认为可用于开发抗艾滋病新药。
General description
二巯丙醇用作螯合剂，可与某些重金属形成稳定的络合物，如砷、汞和铅。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
233.6 °F - closed cup
flash_point_c
112 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Metal chelators and neurotoxicity: lead, mercury, and arsenic
Bjorklund G, et al.
Archives of Toxicology, 91(12), 3787-3797 (2017)
S Kubota et al.
AIDS research and human retroviruses, 6(7), 919-927 (1990-07-01)
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional
Raoul Herbrecht et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(5), 713-720 (2014-11-22)
Strict definition of invasive aspergillosis (IA) cases is required to allow precise conclusions about the efficacy of antifungal therapy. The Global Comparative Aspergillus Study (GCAS) compared voriconazole to amphotericin B (AmB) deoxycholate for the primary therapy of IA. Because predefined
Megan O'Reilly et al.
American journal of physiology. Lung cellular and molecular physiology, 307(12), L948-L958 (2014-10-12)
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have enabled the survival of infants born as early as 23-24 wk of gestation, the challenge of promoting lung growth
R Vos et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(12), 2736-2748 (2014-11-15)
Lymphocytic airway inflammation is a major risk factor for chronic lung allograft dysfunction, for which there is no established treatment. We investigated whether azithromycin could control lymphocytic airway inflammation and improve allograft function. Fifteen lung transplant recipients demonstrating acute allograft
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