D115207
6-甲基尿嘧啶
97%
别名:
2,4-二羟基-6-甲基嘧啶
质量水平
方案
97%
表单
powder
mp
318 °C (dec.) (lit.)
SMILES字符串
CC1=CC(=O)NC(=O)N1
InChI
1S/C5H6N2O2/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9)
InChI key
SHVCSCWHWMSGTE-UHFFFAOYSA-N
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Zhiqiang Guo et al.
Bioorganic & medicinal chemistry letters, 13(19), 3311-3315 (2003-09-03)
The novel synthesis and SAR studies of 6-methyluracils as human GnRH receptor antagonists are discussed. Introduction of a small methyl substituent at the beta-position from N3 of the uracil improved the GnRH binding potency by 5- to 10-fold. The best
Adrian Häberli et al.
Nucleosides, nucleotides & nucleic acids, 22(5-8), 1187-1189 (2003-10-21)
We synthesized pyrrolidino-C-nucleosides, incorporated them into oligodeoxynucleotides and investigated their pairing properties. The thermal duplex and triplex stabilities were measured. While triplex formation is destabilized in the case of pyrrolidino-pseudo-U and -T, pyrrolidino-pseudo-iso-C leads to an increase of the Tm
Effect of tetraalkylammonium derivatives of 6-methyluracil on the endplate potentials of muscles of different functional types.
I V Kovyazina et al.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 399, 458-460 (2005-02-19)
Lars Holland et al.
Inorganic chemistry, 46(26), 11356-11365 (2007-12-01)
The reaction of K2PtCl4 with an excess of 1-methyluracilate (1-MeU) in water at 60 degrees C leads to the formation of two major products, K2[Pt(1-MeU-N3)4].10H2O (1) and trans-K[Pt(1-MeU-N3)2(1-MeU-C5)(H2O)].3H2O (2). Addition of CuCl2 to an aqueous solution of 2 yields the
Konstantin A Petrov et al.
British journal of pharmacology, 163(4), 732-744 (2011-01-15)
The rat respiratory muscle diaphragm has markedly lower sensitivity than the locomotor muscle extensor digitorum longus (EDL) to the new acetylcholinesterase (AChE) inhibitors, alkylammonium derivatives of 6-methyluracil (ADEMS). This study evaluated several possible reasons for differing sensitivity between the diaphragm
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