D5146
重氮烷基脲
≥95%
别名:
1-[1,3-双(羟甲基)-2,5-二酮-4-咪唑烷基]-1,3-双(羟甲基)脲, N-[1,3-双(羟甲基)-2,5-二氧-4-咪唑烷基]-N,N′-双(羟甲基)脲, N-羟甲基-N-[1,3-二(羟甲基)-2,5-二酮-4-咪唑烷基]-N′-羟甲基脲, 重氮烷基脲
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关于此项目
经验公式（希尔记法）:
C8H14N4O7
化学文摘社编号:
分子量:
278.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
278-928-2
MDL number:
Assay:
≥95%
Form:
powder
InChI
1S/C8H14N4O7/c13-1-9-7(18)10(2-14)5-6(17)12(4-16)8(19)11(5)3-15/h5,13-16H,1-4H2,(H,9,18)
InChI key
SOROIESOUPGGFO-UHFFFAOYSA-N
SMILES string
OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O
assay
≥95%
form
powder
storage temp.
2-8°C
Quality Level
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General description
二唑烷基脲是脲衍生物，通常用作化妆品和个人护理产品中的防腐剂和抗菌剂。
Application
- 化妆品防腐剂对皮肤细胞的影响：该文研究各种化妆品防腐剂（包括重氮咪唑烷基脲）对人类健康皮肤细胞的影响，着重说明细胞反应和对皮肤健康的潜在影响(Głaz et al., 2023)。
- 个人护理品中的甲醛释放剂：该研究是一份全面的临床综述，讨论甲醛和甲醛释放剂（如，双咪唑烷基脲）引起的变应性接触性皮炎，加深了解皮肤科中的过敏反应和安全问题 (Goossens and Aerts, 2022)。
- 化妆品成分的潜在致癌作用：研究含有重氮咪唑烷基脲化妆品中的潜在致癌物，着重说明其用于化妆品制剂的安全性和监管问题(Balwierz et al., 2023)。
- 斑贴试验检测变应原敏感性：该研究进行的斑贴试验系列包括重氮咪唑烷基脲，用于检测患者的皮肤致敏性和过敏反应，有助评估它的过敏潜力(Bizjak et al., 2022)。
Disclaimer
本品不可用作全球生物杀灭剂法规监管的生物杀灭剂，包括但不限于：美国联邦杀虫剂、杀菌剂和灭鼠剂法(US EPA′s Federal Insecticide Fungicide and Rodenticide Act)、欧盟生物杀灭剂法规(European Biocidal Products Regulation)、加拿大虫害管理监管机构(Canada’s Pest Management Regulatory Agency)、土耳其生物杀灭剂法规(Turkey’s Biocidal Products Regulation)、韩国生物杀灭剂法(Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR))等。
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Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Claus Zachariae et al.
Contact dermatitis, 54(1), 21-24 (2006-01-24)
The morphology of early allergic contact dermatitis reactions was studied in formaldehyde allergic individuals exposed to a cream product preserved with 4 different concentrations of diazolidinyl urea. The study was made using a dose-escalating design in 3 different anatomical regions
The different decomposition properties of diazolidinyl urea in cosmetics and patch test materials
Doi, et al.
Contact Dermatitis, 65, 81-91 (2011)
Daeryl E Amponin et al.
BMC ophthalmology, 20(1), 28-28 (2020-01-17)
Corneal infections with antibiotic-resistant microorganisms are an increasingly difficult management challenge and chemically or photochemically cross-linking the cornea for therapy presents a unique approach to managing such infections since both direct microbial pathogens killing and matrix stabilization can occur simultaneously.
Diazolidinyl urea: incidence of sensitivity, patterns of cross?reactivity and clinical relevance.
Hectorne KJ & Fransway AF
Contact Dermatitis, 30(1), 16-19 (1994)
Claus Zachariae et al.
Contact dermatitis, 53(5), 268-277 (2005-11-15)
The elicitation potential of the cosmetic preservative diazolidinyl urea was studied in formaldehyde- and diazolidinyl urea-sensitized volunteer patients using a stepwise controlled exposure design. The test product was a facial moisturizer, preserved with varying concentrations of diazolidinyl urea, ranging from
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