所有图片(1)

文件

M14951

5-甲氧基吲哚-2-羧酸

Name: 5-甲氧基吲哚-2-羧酸
Brand: ALDRICH

97%

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所有图片(1)

别名:

NSC 30927

经验公式（希尔记法）:

C₁₀H₉NO₃

CAS号:

4382-54-1

分子量:

191.18

Beilstein:

157478

EC 号:

224-487-6

MDL编号:

MFCD00005614

PubChem化学物质编号:

24896653

NACRES:

NA.22

检测方案

97%

mp

199-201 °C (lit.)

SMILES string

COc1ccc2[nH]c(cc2c1)C(O)=O

InChI

1S/C10H9NO3/c1-14-7-2-3-8-6(4-7)5-9(11-8)10(12)13/h2-5,11H,1H3,(H,12,13)

InChI key

YEBJVSLNUMZXRJ-UHFFFAOYSA-N

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应用

Reactant for preparation of:

Anticancer agents
A fluorescent small molecule probe for in vivo lipid imaging
Indoleamine 2,3-dioxygenase (IDO) inhibitors
Selective Dopamine D3 receptor ligands
5-HT4 receptor ligands
Inhibitors of Mycobacterium tuberculosis pantothenate synthetase
Hypoxia selective cytotoxins
Potent antitumor bifunctional DNA alkylating agents

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Post-ischemic administration of 5-methoxyindole-2-carboxylic acid at the onset of reperfusion affords neuroprotection against stroke injury by preserving mitochondrial function and attenuating oxidative stress.

Jinzi Wu et al.

Biochemical and biophysical research communications, 497(1), 444-450 (2018-02-16)

We previously reported that 5-methoxyindole-2-carboxylic acid (MICA) could induce preconditioning effect in the ischemic brain of rat. In the present study, we addressed the question of whether MICA could also trigger a postconditioning effect in ischemic stroke. To this end

Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke.

Nathalie Sumien et al.

Behavioural brain research, 378, 112278-112278 (2019-10-21)

Stroke leads to devastating outcomes including impairments of sensorimotor and cognitive function that may be long lasting. New intervention strategies are needed to overcome the long-lasting effects of ischemic injury. Previous studies determined that treatment with 5-methoxyindole-2-carboxylic acid (MICA) conferred

Comparison of the Inducing Effect of Indole Compounds on Medusa Formation in Different Classes of Medusozoa.

Luna Yamamori et al.

Zoological science, 34(3), 173-178 (2017-06-08)

Scyphozoa, Cubozoa and Hydrozoa are classes in the phylum Cnidaria that undergo metagenesis involving a dramatic morphological transition. In Scyphozoa and Cubozoa, when exposed to species- or strain-specific transition-inducing stimuli, asexually reproducing benthic polyps transform into sexually reproducing planktonic medusae.

Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury.

Jinzi Wu et al.

Free radical biology & medicine, 113, 244-254 (2017-10-12)

The objective of this study was to investigate a possible role of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as a chemical preconditioning target for neuroprotection against ischemic injury. We used 5-methoxyindole-2-carboxylic acid (MICA), a reportedly reversible DLDH inhibitor, as the preconditioning agent

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