P21005
4-苯基丁酸
99%
别名:
γ-苯基丁酸, ψ-苯基丁酸, 4-苯基丁酸, 4-苯基正丁酸, 苯丁酸
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关于此项目
线性分子式:
C6H5(CH2)3COOH
化学文摘社编号:
分子量:
164.20
Beilstein:
638180
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
99%
表单
crystals
沸点
165 °C/10 mmHg (lit.)
mp
49-51 °C (lit.)
SMILES字符串
OC(=O)CCCc1ccccc1
InChI
1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)
InChI key
OBKXEAXTFZPCHS-UHFFFAOYSA-N
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一般描述
4-苯丁酸(4-PBA)可用于治疗尿素循环代谢障碍。
应用
4-PBA已被用作内质网应激(ERS)的选择性抑制剂。
还可用作合成以下物质的反应剂：
还可用作合成以下物质的反应剂：
- 使用路易斯酸催化剂的1-四氢萘酮。
- 4,N-二苯基丁酰胺。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Clean, reusable and low cost heterogeneous catalyst for amide synthesis
Comerford JW, et al.
Chemical Communications (Cambridge, England), 18(21), 2562-2564 (2009)
Synthesis of 1-tetralones by intramolecular Friedel?Crafts reaction of 4-arylbutyric acids using Lewis acid catalysts
Cui DM, et al.
Tetrahedron Letters, 44(21), 4007-4010 (2003)
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.
Kolb PS, et al.
The International Journal of Biochemistry & Cell Biology, 61, 45-52 (2015)
George A Diaz et al.
Hepatology (Baltimore, Md.), 57(6), 2171-2179 (2012-09-11)
Glycerol phenylbutyrate is under development for treatment of urea cycle disorders (UCDs), rare inherited metabolic disorders manifested by hyperammonemia and neurological impairment. We report the results of a pivotal Phase 3, randomized, double-blind, crossover trial comparing ammonia control, assessed as
Induction of apoptosis coupled to endoplasmic reticulum stress through regulation of CHOP and JNK in bone marrow mesenchymal stem cells from patients with systemic lupus erythematosus
Guo G, et al.
Journal of immunology research (2015)
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