P55805
嘌呤
98%
别名:
7H-咪唑[4,5-d]嘧啶
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关于此项目
经验公式（希尔记法）:
C5H4N4
化学文摘社编号:
分子量:
120.11
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
204-421-2
Beilstein/REAXYS Number:
3200
MDL number:
Assay:
98%
Form:
powder
InChI key
KDCGOANMDULRCW-UHFFFAOYSA-N
InChI
1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)
SMILES string
c1ncc2nc[nH]c2n1
assay
98%
form
powder
mp
214-217 °C (lit.)
Quality Level
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Application
在钯催化剂存在时，嘌呤可直接进行 C-H 功能化，形成各种生物学重要产品。
General description
嘌呤是一种杂环有机化合物，由一个嘧啶环与一个咪唑环融合而成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
New developments in direct functionalization of C-H and N-H bonds of purine bases via metal catalyzed cross-coupling reactions.
Abdoli M, et al.
Royal Society of Chemistry Advances, 55(5), 44371-44389 (2015)
Benshang Li et al.
Nature medicine, 21(6), 563-571 (2015-05-12)
Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which
Silvia Meneghesso et al.
ChemMedChem, 8(3), 415-425 (2013-02-07)
2'-Fluoro-2'-deoxyguanosine has been reported to have potent anti-influenza virus activity in vitro and in vivo. Herein we describe the synthesis and biological evaluation of 6-modified 2'-fluoro-2'-deoxyguanosine analogues and their corresponding phosphoramidate ProTides as potential anti-influenza virus agents. Whereas the parent
Elijah Oyoo-Okoth et al.
Aquatic toxicology (Amsterdam, Netherlands), 124-125, 34-40 (2012-08-14)
Infestation of fish by endoparasites may potentially influence metal uptake and elimination by the host. We quantified the metal uptake rate constant (k(u)) and efflux rate constants (k(e)) of radiolabeled Cd and Co in the cyprinid fish Rastrineobola argentea experimentally
G Burnstock
Cellular and molecular life sciences : CMLS, 64(12), 1471-1483 (2007-03-22)
Adenosine 5'-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signalling molecule via a rich array of receptors, which have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of ATP, produced after
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