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800815C

Avanti

16:0-18:1 DG

1-palmitoyl-2-oleoyl-sn-glycerol, chloroform

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别名:
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol; DG(16:0/18:1(9Z)/0:0)
Empirical Formula (Hill Notation):
C37H70O5
CAS号:
分子量:
594.95
NACRES:
NA.25

检测方案

>99% (TLC)

形式

liquid

包装

pkg of 1 × 5 mL (800815C-10mg)
pkg of 1 × 5 mL (800815C-25mg)
pkg of 1 × 8 mL (800815C-200mg)

manufacturer/tradename

Avanti Polar Lipids 800815C

浓度

2 mg/mL (800815C-10mg)
25 mg/mL (800815C-200mg)
5 mg/mL (800815C-25mg)

lipid type

neutral glycerides
neutral lipids

运输

dry ice

储存温度

−20°C

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此商品
800815O840457P840457C
16:0-18:1 DG 1-palmitoyl-2-oleoyl-sn-glycerol, chloroform

Avanti

800815C

16:0-18:1 DG

16:0-18:1 DG 1-palmitoyl-2-oleoyl-sn-glycerol, neat oil

Avanti

800815O

16:0-18:1 DG

16:0-18:1 PG Avanti Polar Lipids

Avanti

840457P

16:0-18:1 PG

form

liquid

form

liquid

form

powder

form

liquid

packaging

pkg of 1 × 5 mL (800815C-10mg), pkg of 1 × 5 mL (800815C-25mg), pkg of 1 × 8 mL (800815C-200mg)

packaging

pkg of 1 × 10 mg (with screw cap (800815O-10mg)), pkg of 2 × 100 mg (with screw cap 800815O-20)0mg), pkg of 1 × 25 mg (with screw cap (800815O-25mg))

packaging

pkg of 1 × 1 g (840457P-1g), pkg of 2 × 100 mg (840457P-200mg), pkg of 5 × 100 mg (840457P-500mg), pkg of 1 × 25 mg (840457P-25mg)

packaging

pkg of 1 × 2.5 mL (840457C-25mg), pkg of 2 × 20 mL (840457C-1g), pkg of 2 × 4 mL (840457C-200mg), pkg of 5 × 4 mL (840457C-500mg)

manufacturer/tradename

Avanti Polar Lipids 800815C

manufacturer/tradename

Avanti Polar Lipids 800815O

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

concentration

2 mg/mL (800815C-10mg), 25 mg/mL (800815C-200mg), 5 mg/mL (800815C-25mg)

concentration

-

concentration

-

concentration

10 mg/mL (840457C-25mg), 25 mg/mL (840457C-1g), 25 mg/mL (840457C-200mg), 25 mg/mL (840457C-500mg)

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

一般描述

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

应用

16:0-18:1 DG has been used to spike brain samples for mass spectrometric analysis. It may be used as benchmark dataset lipid in collision induced dissociation tandem mass spectrometry (CID-MS/MS) experiments and in in vitro diacylglycerol kinase assay.

包装

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800815C-10mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800815C-200mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800815C-25mg)

储存及稳定性

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

其他说明

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

易制毒化学品(2类)
危险化学品

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CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens
De Jong A, et al.
Nature Immunology, 15(2), 177-177 (2014)
Diacylglycerol kinase delta and sphingomyelin synthase-related protein functionally interact via their sterile alpha motif domains
Murakami C, et al.
The Journal of Biological Chemistry, 295(10), 2932-2947 (2020)
Quantification of signaling lipids by nano-electrospray ionization tandem mass spectrometry (Nano-ESI MS/MS)
Haag M, et al.
Metabolites, 2(1), 57-76 (2012)
Chiaki Murakami et al.
The Journal of biological chemistry, 295(10), 2932-2947 (2020-01-26)
The δ isozyme of diacylglycerol kinase (DGKδ) plays critical roles in lipid signaling by converting diacylglycerol (DG) to phosphatidic acid (PA). We previously demonstrated that DGKδ preferably phosphorylates palmitic acid (16:0)- and/or palmitoleic acid (16:1)-containing DG molecular species, but not
Xinxing Zhang et al.
Journal of the American Chemical Society (2018-11-22)
Nature carefully designs the components of amphiphile-composed monolayer and bilayer membranes to deliver specific functions. The compositions of these interfacial layered structures are so delicate that minute modifications can result in huge changes in function. Great efforts have been expended

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