Merck
CN

850464P

Avanti

18:0-14:0 PC

1-stearoyl-2-myristoyl-sn-glycero-3-phosphocholine, powder

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别名:
1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine; SMPC; PC(18:0/14:0)
Empirical Formula (Hill Notation):
C40H80NO8P
分子量:
734.04
NACRES:
NA.25

检测方案

>99% (TLC)

形式

powder

包装

pkg of 1 × 25 mg (850464P-25mg)

manufacturer/tradename

Avanti Polar Lipids 850464P

lipid type

cardiolipins
phospholipids

运输

dry ice

储存温度

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

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18:0-14:0 PC 1-stearoyl-2-myristoyl-sn-glycero-3-phosphocholine, powder

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850464P

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18:1-14:0 PC 1-oleoyl-2-myristoyl-sn-glycero-3-phosphocholine, powder

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16:0-14:0 PC 1-palmitoyl-2-myristoyl-sn-glycero-3-phosphocholine, powder

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16:0-14:0 PC

form

powder

form

liquid

form

powder

form

powder

packaging

pkg of 1 × 25 mg (850464P-25mg)

packaging

pkg of 1 × 2.5 mL (850464C-25mg)

packaging

pkg of 5 × 100 mg (850474P-500mg), pkg of 1 × 25 mg (850474P-25mg)

packaging

pkg of 1 × 25 mg (850454P-25mg)

manufacturer/tradename

Avanti Polar Lipids 850464P

manufacturer/tradename

Avanti Polar Lipids 850464C

manufacturer/tradename

Avanti Polar Lipids 850474P

manufacturer/tradename

Avanti Polar Lipids 850454P

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

一般描述

Phosphatidylcholine (PC) is a choline containing, zwitterionic phospholipid. It is the abundant phospholipid, constituting between 30-60%. PC has a head group consisting of phosphate, choline and glycerol esterified at C1 and C2 positions with long-chain fatty acyl alcohol. In the structure, quaternary amine choline is essential for its function. The tail group contains both saturated and unsaturated long-chain fatty acyl alcohol. In eukaryotes, the fatty acid chain length may vary up to C26.
Phosphatidylcholines (PCs) are phospholipids, that are abundantly present in the membrane. The fatty acids in the sn-1 and sn-2 positions of PCs are covalently attached to a glycerol with the help of ester bonds.

应用

18:0-14:0 PC (1-stearoyl-2-myristoyl-sn-glycero-3-phosphocholine) has been used:
  • as a standard for ultraperformance liquid chromatography-triple quadrupole time-of-flight mass spectrometry (UPLC–QTOF) for the lipid profiling of human plasma
  • as a standard for liquid chromatography-mass spectrometry(LC-MS)
  • in vesicle preparation

18:0-14:0 PC (1-stearoyl-2-myristoyl-sn-glycero-3-phosphocholine) may be used in liposomes to study its interference in the proliferation of several cell lines by transmission electron microscopy (TEM).

生化/生理作用

Phosphatidylcholine (PC) is the precursor for the synthesis of sphingomyelin and phosphatidylserine. PC is essential for the synthesis of second messengers like fatty acids, diacylglycerol (DAG), phosphatidic acid (PA) and lysophosphatidylcholine. The primary source of PC in the mammals is through Cytidine diphosphate (CDP)-choline/Kennedy pathway by the utilization of choline. 18:0-14:0 PC (1-stearoyl-2-myristoyl-sn-glycero-3-phosphocholine/SMPC) has two saturated chains of stearoyl (C18) and myristoyl (C14). The vesicles formed by SMPC behaves like solid shells and exhibit only weak shape fluctuations.
Phosphatidylcholine (PC) may participate in the signaling of neuronal differentiation.

包装

5 mL Amber Glass Screw Cap Vial (850464P-25mg)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Microenvironmental differences and changes in bilayers of unilamellar vesicles probed by spectroscopic and kinetic parameters
Wen S, et al.
Journal of Colloid and Interface Science, 278(2), 488-496 (2004)
Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics
Lee H, et al.
Chemistry and Physics of Lipids, 214, 69-83 (2018)
Development of lipidomic platform and phosphatidylcholine retention time index for lipid profiling of rosuvastatin treated human plasma
Choi JM, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 944, 157-165 (2014)
Bending stiffness of biological membranes: What can be measured by neutron spin echo?
Mell M, et al.
The European physical journal. E, Soft matter, 36(7), 75-75 (2013)
Biochemistry of Lipids, Lipoproteins and Membranes (2015)

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