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880720P

Avanti

18:0 PEG1000 PE

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] (ammonium salt), powder

CAS号:
NACRES:
NA.25

形式

powder

包装

pkg of 1 × 200 mg (880720P-200mg)
pkg of 1 × 25 mg (880720P-25mg)

运输

dry ice

储存温度

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]

一般描述

The molecular weight and exact mass are averages based on the polydispersity of polyethylene glycol (PEG).

应用

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] (18:0 PEG1000 PE) might be used to prepare sterically stabilized liposome and study its characteristics by small-angle X-ray scattering (SAXS) method. It is also suitable for use in cholesterol-free, PEGylated (CF-PEG) liposomes to study its long term stability when loaded with a hydrophilic drug, carboplatin.

生化/生理作用

Phosphoethanolamine (PE) serves as a substrate for several phospholipids of the cell membrane. It is associated with phospholipid turnover. PE is also found to prevent tumor progression.

包装

5 mL Amber Glass Screw Cap Vial (880720P-25mg)
5 mL Amber Glass Screw Cap Vial (880720P-200mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

分析证书

原产地证书 (CofO)

更多文件

Z Varga et al.
Chemistry and physics of lipids, 165(4), 387-392 (2012-01-10)
Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG)...
Anumita Chaudhury et al.
International journal of pharmaceutics, 430(1-2), 167-175 (2012-04-28)
The obstacles in translating liposome formulations into marketable products could be attributed to their physical instabilities upon long-term storage as aqueous dispersions. Lyophilization is the most commonly used technique to improve physical stability of liposomes. The development of stable, lyophilized...
Adilson Kleber Ferreira et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 67(6), 481-487 (2013-06-19)
Phosphoethanolamine (Pho-s) is a compound involved in phospholipid turnover, acting as a substrate for many phospholipids of the cell membranes. In a recent study, we showed that Pho-s has antitumor effect in the several tumor cells. In this study we...
Brian J Nablo et al.
Biophysical journal, 95(3), 1157-1164 (2008-07-23)
Nonelectrolyte polymers of poly(ethylene glycol) (PEG) were used to estimate the diameter of the ion channel formed by the Bacillus anthracis protective antigen 63 (PA(63)). Based on the ability of different molecular weight PEGs to partition into the pore and...

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