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890700C

Avanti

12:0 EPC (Cl Salt)

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (chloride salt), chloroform

Empirical Formula (Hill Notation):
C34H69NO8PCl
CAS号:
分子量:
686.34
NACRES:
NA.25

包装

pkg of 1 × 1 mL (890700C-10mg)

浓度

10 mg/mL (890700C-10mg)

运输

dry ice

储存温度

−20°C

SMILES string

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)OCC.[Cl-]

一般描述

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is a cationic phospholipid. 12:0 EPC is a short chain analog of dioleoyl ethylphosphatidylcholine. O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

应用

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC (Cl Salt)) is suitable:
  • for use in lipoplex
  • to study its effect on transfection of human umbilical artery endothelial cells (HUAEC)
  • in liposome preparation
  • in lipid mixtures to study its cubic phases of formation, stability and phase transitions

生化/生理作用

Chemically synthesized cationic lipids are applicable as non-viral gene carriers. Variation in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency. 1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is preferred for transfection of cultured primary endothelial cells. 12:0 EPC forms lamellar lipoplexes possessing high to superior transfection activity.

包装

5 mL Clear Glass Sealed Ampule (890700C-10mg)

分析证书

原产地证书 (CofO)

更多文件

L Wang et al.
Gene therapy, 11(17), 1358-1362 (2004-06-25)
To date, the primary approach to improve the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths or the inclusion of noncationic helper lipids. Here, it is reported that an alternative approach can be...
Analysis of lipoplex structure and lipid phase changes
Liposomes, 399-423 (2010)
Boris Tenchov et al.
Chemistry and physics of lipids, 208, 65-74 (2017-10-07)
The non-lamellar phases formed by membrane lipids in diluted aqueous dispersions are mainly represented by the inverted hexagonal phase, HII, and phases of cubic symmetry, among them the bicontinuous cubic phases Pn3m (Q224), Im3m (Q229) and Ia3d (Q230). Here we...
Rumiana Koynova et al.
The journal of physical chemistry. B, 111(27), 7786-7795 (2007-06-19)
Some mixtures of two cationic lipids including phospholipid compounds (O-ethylphosphatidylcholines) as well as common, commercially available cationic lipids, such as dimethylammonium bromides and trimethylammonium propanes, deliver therapeutic DNA considerably more efficiently than do the separate molecules. In an effort to...
Rumiana Koynova et al.
Molecular pharmaceutics, 6(3), 951-958 (2009-04-04)
Synthetic cationic lipids are widely used components of nonviral gene carriers, and the factors regulating their transfection efficiency are the subject of considerable interest. In view of the important role that electrostatic interactions with the polyanionic nucleic acids play in...

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