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Merck
CN

100065

二苯基硼酸-2-氨基乙酯

≥97% (titration), crystalline solid, Ins(1,4,5)P3-induced Ca2+ release inhibitor, Calbiochem®

别名:

二苯基硼酸-2-氨基乙酯, 2-氨基乙氧基二苯基硼酸酯，（2-氨基乙氧基）二苯基硼烷

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关于此项目

经验公式（希尔记法）:
C14H16BNO
化学文摘社编号:
524-95-8
分子量:
225.09
MDL编号:
MFCD00014823
UNSPSC代码:
12352200
NACRES:
NA.77

主要文件

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产品名称

二苯基硼酸-2-氨基乙酯, A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.

质量水平

100

描述

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
RTECS - ED6150000

方案

≥97% (titration)

表单

crystalline solid

制造商/商品名称

Calbiochem®

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

DMSO: 20 mg/mL
95% ethanol: 25 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

B(OCCN)(c2ccccc2)c1ccccc1

InChI

1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2

InChI key

BLZVCIGGICSWIG-UHFFFAOYSA-N

相关类别

一般描述

Ins（1,4,5）P3诱导Ca2+释放的细胞渗透性调节剂。可抑制大鼠小脑微粒体中Ins（1,4,5）P3诱导的Ca2+释放（IC50 = 42 µM），且不会影响[3H]-Ins（1,4,5）P3 与其受体的结合。在肝细胞中，2-APB可通过一种可能涉及其与通道蛋白或相关调节蛋白结合的机制，来抑制Ca2+库通道。其对Ca2+从对精氨酸敏感的Ca2+库（由大鼠腿部骨骼肌和心脏中制备得到）中释放没有影响。

生化/生理作用

主要靶标
Ins（1,4,5）P3诱导的Ca2+释放
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：42 µM，抑制Ins（1,4,5）P3诱导的大鼠小脑微粒体制剂中Ca2+的释放

包装

用惰性气体包装

制备说明

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存2个月。

其他说明

Brooke, R. T., et al. 2004.Lab. Invest.84, 29.
Gregory, R.B., et al. 2001.Biochem.J.354, 285.
Ma, H.T., et al. 2001.J. Biol. Chem.276, 18888.
Ascher-Landsberg, S., et al. 1999.Biochem.Biophys.Res. Commun.264, 979.
Maruyama, T., et al. 1997.J. Biochem.122, 498.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性：标准处理（A）

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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