52332
苯甲基磺酰氟
Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.
别名:
苯甲基磺酰氟, 苄基磺酰氟，PMSF
质量水平
描述
RTECS - XT8040000
方案
≥99% (GC)
表单
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
颜色
white to off-white
溶解性
ethanol: soluble
isopropanol: soluble
methanol: soluble
运输
ambient
储存温度
10-30°C
SMILES字符串
F[S](=O)(=O)Cc1ccccc1
InChI
1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI key
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
一般描述
丝氨酸蛋白酶的不可逆抑制剂。其作用机理类似于氟磷酸二异丙酯。PMSF引起活性位点丝氨酸残基的磺酰化。还报告抑制未成熟胸腺细胞中的核小体间DNA片段化。有关更稳定的相关抑制剂，请参见AEBSF（目录号101500）。
生化/生理作用
主要靶标
丝氨酸蛋白酶
丝氨酸蛋白酶
产物不与ATP竞争。
可逆：否
细胞渗透性：否
制备说明
pH 7.5下t½ = 1小时。有效浓度：50 μM。
在复溶后存放于冰箱（4°C）。储备溶液在4°C下可稳定保存至多9个月。
其他说明
Seitz, R., et al. 1993.Int. J. Cancer53, 514.
Weaver, V.M., et al. 1993.Biochem.Cell.Biol.71, 488.
Bourgain, R.H., et al. 1992.Adv.Exp.Med. Biol.316, 427.
Chang, C.T., et al. 1992.Biochem.Int.28, 707.
Weaver, V.M., et al. 1993.Biochem.Cell.Biol.71, 488.
Bourgain, R.H., et al. 1992.Adv.Exp.Med. Biol.316, 427.
Chang, C.T., et al. 1992.Biochem.Int.28, 707.
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法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：腐蚀性（L）
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Skin Corr. 1B
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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