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Merck
CN

524400

Phorbol 12-Myristate 13-Acetate

≥98% (HPLC), solid, PKC activator, Calbiochem®

别名:

佛波醇12-十四酸酯13-乙酸酯, TPA，PMA，PKC活化剂I

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关于此项目

经验公式（希尔记法）:
C36H56O8
化学文摘社编号:
16561-29-8
分子量:
616.83
UNSPSC Code:
12352211
NACRES:
NA.77
MDL number:
MFCD00036736

主要文件

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产品名称

佛波醇12-十四酸酯13-乙酸酯, Phorbol-12-myristate-13-acetate, CAS 16561-29-8, is the most common phorbol ester. Activates PKC at nanomolar concentrations.

SMILES string

O([C@]21[C@H]([C@H]3[C@@]([C@H]4[C@](CC(=C3)CO)(C(=O)C(=C4)C)O)([C@@H]([C@H]2OC(=O)CCCCCCCCCCCCC)C)O)C1(C)C)C(=O)C

InChI

1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1

InChI key

PHEDXBVPIONUQT-RGYGYFBISA-N

description

RTECS - QH4377000

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Disclaimer

毒性：有害（C）

Biochem/physiol Actions

产物不与ATP竞争。
可逆性：是
细胞渗透性：否
首要靶标
蛋白激酶C

General description

最常用的佛波醇酯。极强效的小鼠皮肤肿瘤促进剂。即使在nM浓度下也能在体内和体外激活蛋白激酶C。在培养的肝细胞中促进可诱导型NOS的表达。激活Ca2+-ATPase并增强毛喉素诱导的cAMP形成。抑制Fas抗原诱导的凋亡，但在HL-60早幼粒细胞白血病细胞中是诱导凋亡。它的结合是可逆的。也可以提供10 mM的DMSO溶液（目录号500582）。

Other Notes

Powell, D.J., et al. 2003.Mol.Cell Biol.23, 7794.
Tepper, C.G., et al. 1995.Proc.Natl.Acad.Sci. USA92, 8443.
Oishi, K., and Yamaguchi, M. 1994.J. Cell.生物化学。55, 168.
Macfarlane, D.E., and O’Donnell, P.S.1993.Leukemia7, 1846.
Ghandi, V.C. and Jones, D.J., 1992.Neuropharmacol.31, 1101.
Hortelano, S., et al. 1992.J. Biol. Chem. 267, 24937.
Kontny, E., et al. 1992.Eur. J. Pharmacol.227, 333.
Zanaboni, P.B., et al. 1992.J. Appl. Physiol.73, 2011.
Saltis, J., et al. 1991.J. Biol. Chem.266, 261.
Beguinot, L., et al. 1985.Proc.Natl.Acad.Sci. USA82, 2774.
Perchellet, J. 1985.Carcinogenesis6, 567.
Nishizuka, Y. 1984.Science255, 1365.
Mastro, A. 1982.Lymphokines6, 263.

Packaging

用惰性气体包装

Preparation Note

仅在使用前再用水相缓冲液进行稀释。
溶解后，等分并冷冻保存（-20°C）。无水DMSO储备液可在-20°C最长稳定6个月。DMSO储备液在频繁使用时可能会积水。储备液中存在的水将会加速产物的分解，导致在2-3个月内活性的明显下降。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

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