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Merck
CN

553210

Rapamycin

≥95% (HPLC), powder

别名:

Rapamycin

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关于此项目

经验公式（希尔记法）:
C51H79NO13
化学文摘社编号:
53123-88-9
分子量:
914.17
MDL编号:
MFCD00867594
UNSPSC代码:
41116107
NACRES:
NA.77

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质量水平

200

方案

≥95% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

clear

溶解性

DMSO: 200 mg/mL
ethanol: 50 mg/mL

运输

ambient

储存温度

−20°C

InChI key

QFJCIRLUMZQUOT-UQKHEJQMSA-N

一般描述

抗真菌剂和免疫抑制剂。选择性抑制哺乳动物雷帕霉素靶蛋白(mTOR)，并阻断随后的p70 S6激酶激活(IC50 = 50 pM)。可特异性抑制mTORC1，但可磷酸化Akt（蛋白激酶B）Ser473位的mTORC2则对雷帕霉素不敏感。防止 IGF-II 的翻译激活。还防止静止的T细胞进入细胞周期，但不直接阻止细胞周期进程。研究表明，可抑制随后的信号传导事件，例如p110Rb 磷酸化、p34cdc2激酶激活和细胞周期蛋白A合成。表现出与FK-50 6结合蛋白的强结合力。还据报道在鼠B细胞系中诱导凋亡，抑制淋巴因子诱导的细胞增殖（在G1期），并不可逆地阻滞酿酒酵母细胞（在G1）。另提供5 mM (500 µg/109 µl)雷帕霉素DMSO溶液（货号 553211）和10 mM (1 mg/109 µl)雷帕霉素乙醇溶液（货号553212）。
选择性抑制哺乳动物雷帕霉素靶蛋白(mTOR)，并阻断随后的p70 S6激酶激活(IC50 = 50 pM)。可特异性抑制mTORC1，但可磷酸化Akt（蛋白激酶B）Ser473位的mTORC2则对雷帕霉素不敏感。防止 IGF-II 的翻译激活。还防止静止的T细胞进入细胞周期，但不直接阻止细胞周期进程。研究表明，可抑制随后的信号传导事件，例如p110Rb 磷酸化、p34cdc2激酶激活和细胞周期蛋白A合成。表现出与FK-50 6结合蛋白的强结合力。还据报道在鼠B细胞系中诱导凋亡，抑制淋巴因子诱导的细胞增殖（在G1期），并不可逆地阻滞酿酒酵母细胞（在G1期）。

生化/生理作用

主靶
雷帕霉素（mTOR）的哺乳动物靶标
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：50 pM，抑制p70 S6激酶

制备说明

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他说明

Chen, T., et al. 2011.Aging Cell.10, 908.
Powell, D.J., et al. 2003.Mol. cell Biol.23, 7794.
Braun, W., et al. 1995.FASEB J.9, 63.
Nielsen, F.C., et al. 1995.Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F.1994.Cell.Immunol. 156, 493.
Gottschalk, A.R., et al. 1994.Proc.Natl.Acad.Sci. USA91, 7350.
Morice, W.G., et al. 1993.J. Biol. Chem.268, 3734.
Terada, N., et al. 1993.J. Biol. Chem.268, 12062.
Kuo, J., et al. 1992.Nature 358, 70.
Price, D.J., et al. 1992.Science257, 973.
Heitman, J., et al. 1991.Science253, 905.
Kay, J.E., et al. 1991.Immunology72, 544.
Schreiber, S.L.1991.Science251, 283.
Bierer, B.E., et al. 1990.Proc.Natl.Acad.Sci. USA87, 9231.
Dumont, F.J., et al. 1990.J. Immunol.144, 251.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性：标准处理（A）

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H351,H361fd

危险分类

Carc. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

法规信息

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Erika E Kuchen et al.
eLife, 9 (2020-01-24)
Cell heterogeneity may be caused by stochastic or deterministic effects. The inheritance of regulators through cell division is a key deterministic force, but identifying inheritance effects in a systematic manner has been challenging. Here, we measure and analyze cell cycles
Johany Peñailillo et al.
NPJ Regenerative medicine, 6(1), 68-68 (2021-10-24)
Xenopus laevis are able to regenerate the spinal cord during larvae stages through the activation of neural stem progenitor cells (NSPCs). Here we use high-resolution expression profiling to characterize the early transcriptome changes induced after spinal cord injury, aiming to
Zhigang Zhang et al.
Aging, 12(18), 17786-17799 (2020-09-23)
Rapamycin delays multiple age-related conditions and extends lifespan in organisms ranging from yeast to mice. However, the mechanisms by which rapamycin influences longevity are incompletely understood. The objective of this study was to investigate the effect of rapamycin on NAD+/NADH
Christopher A Jackson et al.
eLife, 9 (2020-01-28)
Understanding how gene expression programs are controlled requires identifying regulatory relationships between transcription factors and target genes. Gene regulatory networks are typically constructed from gene expression data acquired following genetic perturbation or environmental stimulus. Single-cell RNA sequencing (scRNAseq) captures the
Isis M Ornelas et al.
Glia, 68(6), 1274-1290 (2020-01-07)
Oligodendrocyte precursor cells (OPCs) differentiate and mature into oligodendrocytes, which produce myelin in the central nervous system. Prior studies have shown that the mechanistic target of rapamycin (mTOR) is necessary for proper myelination of the mouse spinal cord and that
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