MABC28
Anti-RIP3 Antibody, clone 6E6.2
clone 6E6.2, from mouse
别名:
Receptor-interacting serine/threonine-protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3
产品名称
Anti-RIP3 Antibody, clone 6E6.2, clone 6E6.2, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6E6.2, monoclonal
species reactivity
human, rat
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RIPK3(11035)
Analysis Note
Control
Human pancreas tissue lysate
Human pancreas tissue lysate
Evaluated by Western Blot in human pancreas tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected RIP3 in 10 µg of human pancreas tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected RIP3 in 10 µg of human pancreas tissue lysate.
Application
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
This Anti-RIP3 Antibody, clone 6E6.2 is validated for use in WB, IH for the detection of RIP3.
Western Blot Analysis: A 1:1,000 dilution from a representative lot detected RIP3 in 10 µg of human placenta tissue lysate.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected RIP3 in rat pancreas tissue.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected RIP3 in rat pancreas tissue.
Biochem/physiol Actions
This antibody recognizes RIP3 at the N-terminus.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Receptor-interacting protein 3 (RIP3) contains a N-terminal kinase domain and interacts with RIP. The binding of RIP to RIP3 causes the RIP3/RIP complex to be shuttled into the tumor necrosis factor receptor-1 signaling cascade. RIP3 is known to be a very effective apoptosis inducer. Two novel splice variants of RIP3 have been discovered, RIP3 beta and RIP3 gamma, that have shown to decrease apoptosis related to full length RIP3. RIP3 gamma has been shown to be significantly up-regulated in colon and lung cancers and may play a role in tumorigenesis.
~56 kDa (isoform 1) and ~27 kDa (isoform 2) observed.
Isoform 3 (~25 kDa) may be observed in some lysates. An uncharacterized band may be observed at ~16 kDa in some lysates.
Isoform 3 (~25 kDa) may be observed in some lysates. An uncharacterized band may be observed at ~16 kDa in some lysates.
Immunogen
Epitope: N-terminus
GST-tagged recombinant protein corresponding to human RIP3 at the N-terminus.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Anne-Sophie Gary et al.
Cell death discovery, 10(1), 232-232 (2024-05-15)
Ultraviolet radiation (UVR) is a major environmental mutagen. In skin, UVR can initiate cancer through the induction of mutagenic DNA damage and promote its progression. An important cancer prevention mechanism is the regulated cell death (RCD), which can safely dispose
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