MABC28
Anti-RIP3 Antibody, clone 6E6.2
clone 6E6.2, from mouse
别名:
Receptor-interacting serine/threonine-protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3
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25 CM2
CN¥952.79
100 CM2
CN¥3,120.59
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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此商品 | 357243 | 262919 | 357251 |
|---|---|---|---|
| assay ≥99.9% trace metals basis | assay ≥99.9% trace metals basis | assay ≥99.9% trace metals basis | assay ≥99.9% trace metals basis |
| form foil | form foil | form foil | form foil |
| density 16.69 g/cm3 (lit.) | density 16.69 g/cm3 (lit.) | density 16.69 g/cm3 (lit.) | density 16.69 g/cm3 (lit.) |
| bp 5425 °C (lit.) | bp 5425 °C (lit.) | bp 5425 °C (lit.) | bp 5425 °C (lit.) |
| resistivity 13.5 μΩ-cm, 20°C | resistivity 13.5 μΩ-cm, 20°C | resistivity 13.5 μΩ-cm, 20°C | resistivity 13.5 μΩ-cm, 20°C |
| mp 2996 °C (lit.) | mp 2996 °C (lit.) | mp 2996 °C (lit.) | mp 2996 °C (lit.) |
一般描述
Receptor-interacting protein 3 (RIP3) contains a N-terminal kinase domain and interacts with RIP. The binding of RIP to RIP3 causes the RIP3/RIP complex to be shuttled into the tumor necrosis factor receptor-1 signaling cascade. RIP3 is known to be a very effective apoptosis inducer. Two novel splice variants of RIP3 have been discovered, RIP3 beta and RIP3 gamma, that have shown to decrease apoptosis related to full length RIP3. RIP3 gamma has been shown to be significantly up-regulated in colon and lung cancers and may play a role in tumorigenesis.
特异性
This antibody recognizes RIP3 at the N-terminus.
免疫原
Epitope: N-terminus
GST-tagged recombinant protein corresponding to human RIP3 at the N-terminus.
应用
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
This Anti-RIP3 Antibody, clone 6E6.2 is validated for use in WB, IH for the detection of RIP3.
Western Blot Analysis: A 1:1,000 dilution from a representative lot detected RIP3 in 10 µg of human placenta tissue lysate.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected RIP3 in rat pancreas tissue.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected RIP3 in rat pancreas tissue.
质量
Evaluated by Western Blot in human pancreas tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected RIP3 in 10 µg of human pancreas tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected RIP3 in 10 µg of human pancreas tissue lysate.
目标描述
~56 kDa (isoform 1) and ~27 kDa (isoform 2) observed.
Isoform 3 (~25 kDa) may be observed in some lysates. An uncharacterized band may be observed at ~16 kDa in some lysates.
Isoform 3 (~25 kDa) may be observed in some lysates. An uncharacterized band may be observed at ~16 kDa in some lysates.
外形
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Human pancreas tissue lysate
Human pancreas tissue lysate
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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