Merck
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文件

E3876

Sigma-Aldrich

N -乙基马来酰亚胺

crystalline, ≥98% (HPLC)

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别名:
NEM
经验公式（希尔记法）:
C6H7NO2
CAS号:
128-53-0
分子量:
125.13
Beilstein:
112448
EC 号:
204-892-4
MDL编号:
MFCD00005509
PubChem化学物质编号:
24278420
NACRES:
NA.21

生物来源

synthetic (organic)

质量水平

200

检测方案

≥98% (HPLC)

形式

crystalline

储存条件

(Tightly closed. Dry. Keep in a well-ventilated place. )

颜色

white to faint yellow

bp

210 °C (lit.)

mp

43-46 °C (lit.)

溶解性

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faint yellow or tan

储存温度

2-8°C

SMILES string

CCN1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

InChI key

HDFGOPSGAURCEO-UHFFFAOYSA-N

Gene Information

human ... KCNQ2(3785) , KCNQ4(9132) , KCNQ5(56479) , SLC6A3(6531) , SLC6A4(6532)

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应用

用于共价修饰蛋白质的半胱氨酸残基的试剂。

生化/生理作用

使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。
增强来自交感神经元的原生 M 通道的电流，并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。

制备说明

NEM 以 50mg/ml 的浓度溶于乙醇可得到透明的溶液。NEM 可溶于水（在 4ml 水中的溶解量 >50mg）；然而，水溶液却不稳定。水解速率为假一级，并显著依赖于 pH 值。

其他说明

For additional information on our range of Biochemicals, please complete this form.

象形图

CorrosionSkull and crossbones
GHS05,GHS06

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

163.2 °F

闪点(°C)

72.9 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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