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Merck
CN

PHR1181

昂丹司琼杂质F

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

2-甲基咪唑, 2-甲基-1,3-氮杂茂

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关于此项目

经验公式(希尔记法):
C4H6N2
化学文摘社编号:
分子量:
82.10
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
211-765-7
Beilstein/REAXYS Number:
1368
MDL number:
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InChI key

LXBGSDVWAMZHDD-UHFFFAOYSA-N

InChI

1S/C4H6N2/c1-4-5-2-3-6-4/h2-3H,1H3,(H,5,6)

SMILES string

Cc1ncc[nH]1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001320

vapor pressure

<1 mmHg ( 0 °C)

API family

ondansetron

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

267-268 °C (lit.)

mp

142-143 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9000 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


分析证书(COA)

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Jiafeng Geng et al.
Journal of the American Chemical Society, 134(29), 12209-12218 (2012-06-30)
Tryptophan 2,3-dioxygenase (TDO) is a heme-dependent enzyme that catalyzes the oxidative degradation of L-tryptophan (L-Trp) to N-formylkynurenine (NFK). A highly conserved histidine residue in the distal heme pocket has attracted great attention in the mechanistic studies of TDO. However, a
Wenxiang Cao et al.
Biochemistry, 43(22), 7017-7027 (2004-06-02)
We use laser flash photolysis and time-resolved Raman spectroscopy of CO-bound heme complexes to study proximal and distal influences on ligand rebinding kinetics. We report kinetics of CO rebinding to microperoxidase (MP) and 2-methylimidazole ligated Fe protoporphyrin IX in the
Janosch Cravillon et al.
Angewandte Chemie (International ed. in English), 50(35), 8067-8071 (2011-07-13)
Prenucleation clusters: in situ synchrotron X-ray scattering with a one-second time resolution revealed the occurrence of nano-sized clusters during the nucleation and early growth of nanocrystals of a zeolitic imidazolate framework (ZIF). The complex crystallization process exhibits similarities with crystallization processes
R N Patel et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 58(13), 2961-2969 (2002-12-13)
Bridged homobinuclear (copper-copper) and heterobinuclear (copper-zinc) complexes of diethylenetriamine have been prepared with 2-methyl-imidazole as bridging ligand. EPR spectra of the polycrystalline complexes have been studied at room temperature and also at liquid nitrogen temperature. Low temperature EPR and electronic
Cristina Maccallini et al.
Bioorganic & medicinal chemistry letters, 20(22), 6495-6499 (2010-10-12)
A series of N-substituted acetamidines and 2-methylimidazole derivatives structurally related to W1400 were synthesized and evaluated as Nitric Oxide Synthase (NOS) inhibitors. Analogs with sterically hindering isopropyl and phenyl substituents on the benzylic carbon connecting the aromatic core of W1400

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