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文件

Y0000588

文拉法辛

Name: 文拉法辛
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

文拉法辛盐酸盐, (+/-)-1-[2-(二甲基氨基)-1-(4-甲氧基苯基)乙基]环己醇盐酸盐, 盐酸文拉法辛

经验公式（希尔记法）:

C₁₇H₂₇NO₂ · HCl

CAS号:

99300-78-4

分子量:

313.86

MDL编号:

MFCD03658865

PubChem化学物质编号:

329831037

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

venlafaxine

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2

InChI

1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

InChI key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

基因信息

human ... SLC6A2(6530) , SLC6A4(6532)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Venlafaxine for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

文拉法辛是抗抑郁药。文拉法辛在人中的抗抑郁作用机制与其在中枢神经系统中神经递质活性的增强有关。文拉法辛是神经元 5-羟色胺和去甲肾上腺素再摄取的有效抑制剂，是多巴胺再摄取的弱抑制剂。在体外，文拉法辛对毒蕈碱、组胺能或 α-1 肾上腺素能受体无明显活性。文拉法辛不具有 MAO 抑制剂活性。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

危险分类

Aquatic Chronic 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer.

Mara Z Vitolins et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(32), 4092-4098 (2013-10-02)

Hot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men. Eligible androgen-deprived men were randomly assigned to one of four daily regimens (2 × 2 factorial design) for 12

Association between reported venlafaxine use in early pregnancy and birth defects, national birth defects prevention study, 1997-2007.

Kara N D Polen et al.

Birth defects research. Part A, Clinical and molecular teratology, 97(1), 28-35 (2013-01-03)

Few epidemiologic studies have investigated the use of venlafaxine (Effexor XR capsules, Product Monograph, Wyeth, Montreal, Canada), an antidepressant used to treat major depression and anxiety disorders in adults, during pregnancy. Our objective was to determine whether use of venlafaxine

Ex vivo permeation characteristics of venlafaxine through sheep nasal mucosa.

Swati Pund et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 195-201 (2012-11-20)

Venlafaxine, a dual acting antidepressant is a new therapeutic option for chronic depression. Depression is a common mental disorder associated with the abnormalities in neuronal transport in the brain. Since the nose-to-brain pathway has been indicated for delivering drugs to

Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment.

Aaron S Heller et al.

The American journal of psychiatry, 170(2), 197-206 (2012-12-12)

OBJECTIVE Deficits in positive affect and their neural bases have been associated with major depression. However, whether reductions in positive affect result solely from an overall reduction in nucleus accumbens activity and fronto-striatal connectivity or the additional inability to sustain

Treating wastewater from a pharmaceutical formulation facility by biological process and ozone.

Yaal Lester et al.

Water research, 47(13), 4349-4356 (2013-06-15)

Wastewater from a pharmaceutical formulation facility (TevaKS, Israel) was treated with a biological activated-sludge system followed by ozonation. The goal was to reduce the concentrations of the drugs carbamazepine (CBZ) and venlafaxine (VLX) before discharging the wastewater to the municipal

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