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Merck
CN

07039

(R)-(+)-α-硫辛酸

≥98.0% (HPLC)

别名:

(R)-(+)-1,2-二硫戊环基-3-戊酸, (R)-6,8-二硫辛酸, (R)-6,8-硫辛酸

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关于此项目

经验公式(希尔记法):
C8H14O2S2
化学文摘社编号:
分子量:
206.33
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.32
MDL number:
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Quality Level

assay

≥98.0% (HPLC)

optical purity

enantiomeric excess: ≥98.0% (HPLC)

mp

48-52 °C (lit.)

storage temp.

−20°C

InChI

1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1

InChI key

AGBQKNBQESQNJD-SSDOTTSWSA-N

Biochem/physiol Actions

(R)-(+)-α-硫辛酸可显著增加丙酮酸氧化,同时消除大鼠肝细胞中的脂肪酸氧化。 这些作用使 R-(+)-α-硫辛酸成为一种有前途的Ⅱ 型糖尿病治疗选择。它是具有促氧化剂活性的生物抗氧化剂 ,其治疗潜力已被广泛研究 ,例如治疗阿尔茨海默病′。

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

Analysis Note

通过 LC-MS 确认同一性


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存储类别

11 - Combustible Solids

wgk

WGK 3



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Dove J Keith et al.
Pharmacological research, 66(3), 199-206 (2012-05-23)
Lipoic acid (LA) shows promise as a beneficial micronutrient toward improving elder health. Studies using old rats show that (R)-α-LA (R-LA) significantly increases low molecular weight antioxidants that otherwise decline with age. Despite this rationale for benefiting human health, little
Jennie L Walgren et al.
Metabolism: clinical and experimental, 53(2), 165-173 (2004-02-10)
R-(+)-alpha-lipoic acid (R-LA) is the naturally occurring enantiomer of LA. It is a strong antioxidant and cofactor of key metabolic enzyme complexes catalyzing the decarboxylation of alpha-keto acids. Racemic LA (rac-LA) has shown promise in treating diabetic polyneuropathy, and some
Annette Maczurek et al.
Advanced drug delivery reviews, 60(13-14), 1463-1470 (2008-07-29)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social environment and the ability to carry out daily activities. Despite extensive research into the pathogenesis of AD, a neuroprotective treatment -



全球贸易项目编号

货号GTIN
N17351-500G04061832113487
N17351-100G04061832113463
07039-10MG04061838647375
703904061838245526
07039-50MG04061833380390
07039-500MG04061833380383