Quality Level
assay
≥98.0% (HPLC)
optical purity
enantiomeric excess: ≥98.0% (HPLC)
mp
48-52 °C (lit.)
storage temp.
−20°C
InChI
1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
InChI key
AGBQKNBQESQNJD-SSDOTTSWSA-N
Biochem/physiol Actions
(R)-(+)-α-硫辛酸可显著增加丙酮酸氧化,同时消除大鼠肝细胞中的脂肪酸氧化。 这些作用使 R-(+)-α-硫辛酸成为一种有前途的Ⅱ 型糖尿病治疗选择。它是具有促氧化剂活性的生物抗氧化剂 ,其治疗潜力已被广泛研究 ,例如治疗阿尔茨海默病′。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
Analysis Note
通过 LC-MS 确认同一性
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存储类别
11 - Combustible Solids
wgk
WGK 3
Dove J Keith et al.
Pharmacological research, 66(3), 199-206 (2012-05-23)
Lipoic acid (LA) shows promise as a beneficial micronutrient toward improving elder health. Studies using old rats show that (R)-α-LA (R-LA) significantly increases low molecular weight antioxidants that otherwise decline with age. Despite this rationale for benefiting human health, little
Jennie L Walgren et al.
Metabolism: clinical and experimental, 53(2), 165-173 (2004-02-10)
R-(+)-alpha-lipoic acid (R-LA) is the naturally occurring enantiomer of LA. It is a strong antioxidant and cofactor of key metabolic enzyme complexes catalyzing the decarboxylation of alpha-keto acids. Racemic LA (rac-LA) has shown promise in treating diabetic polyneuropathy, and some
Annette Maczurek et al.
Advanced drug delivery reviews, 60(13-14), 1463-1470 (2008-07-29)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social environment and the ability to carry out daily activities. Despite extensive research into the pathogenesis of AD, a neuroprotective treatment -
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N17351-500G | 04061832113487 |
| N17351-100G | 04061832113463 |
| 07039-10MG | 04061838647375 |
| 7039 | 04061838245526 |
| 07039-50MG | 04061833380390 |
| 07039-500MG | 04061833380383 |