A1466
N-Acetyl-Trp-Glu-His-Asp-al
≥80% (HPLC), powder
别名:
Ac-WEHD-CHO
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关于此项目
经验公式（希尔记法）:
C28H33N7O9
化学文摘社编号:
分子量:
611.60
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
产品名称
N-Acetyl-Trp-Glu-His-Asp-al, ≥80% (HPLC), powder
InChI
1S/C28H33N7O9/c1-15(37)32-22(8-16-11-30-20-5-3-2-4-19(16)20)28(44)34-21(6-7-24(38)39)26(42)35-23(9-17-12-29-14-31-17)27(43)33-18(13-36)10-25(40)41/h2-5,11-14,18,21-23,30H,6-10H2,1H3,(H,29,31)(H,32,37)(H,33,43)(H,34,44)(H,35,42)(H,38,39)(H,40,41)/t18-,21-,22-,23-/m0/s1
SMILES string
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N[C@@H](CC(O)=O)C=O
InChI key
ZSZYUXBVDPGGGX-QGQQZZQASA-N
assay
≥80% (HPLC)
form
powder
color
white
solubility
H2O: 1 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
Very potent caspase 1 and 5 inhibitor.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Daichi Sadatomi et al.
Journal of biochemistry, 161(6), 503-512 (2017-01-18)
The NLRP3 inflammasome plays a critical role in the processing and release of inflammatory cytokines, such as interleukin-1β (IL-1β) and IL-18. Accumulating evidence suggests that mitochondria are common mediators of NLRP3 inflammasome activation induced by a wide range of inflammatory
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