D3168
Duramycin from Streptoverticillium cinnamoneus
≥90.0%
别名:
Duramycin, Lancovutide
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C89H125N23O25S3
化学文摘社编号:
分子量:
2013.28
MDL编号:
UNSPSC代码:
51102829
NACRES:
NA.85
质量水平
方案
≥90.0%
表单
powder
溶解性
0.1 M HCl: 10 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
protein synthesis | interferes
储存温度
2-8°C
一般描述
Chemical structure: tetracycline
应用
Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe. It is used to stimulate sodium transport in cultured human colonic epithelia.
生化/生理作用
Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. It enhances chloride secretion in airway epithelium.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Soichiro Matsunaga et al.
Langmuir : the ACS journal of surfaces and colloids, 25(14), 8200-8207 (2009-05-13)
We visualized nanometer-scale phospholipid particle fusion by scanning tunneling microscopy (STM) on an alkanethiol-modified gold substrate, induced by duramycin, a tetracyclic antibiotic peptide with 19 amino residues. Ultrasonic homogenization generated a suspension mainly consisting of minimal lipid particles (MLP) from
Ming Zhao et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(8), 1345-1352 (2008-07-18)
With only 19 amino acids, duramycin is the smallest known polypeptide that has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. As an abundant binding target, PtdE is a
Kunihiko Iwamoto et al.
Biophysical journal, 93(5), 1608-1619 (2007-05-08)
Duramycin is a 19-amino-acid tetracyclic lantibiotic closely related to cinnamycin (Ro09-0198), which is known to bind phosphatidylethanolamine (PE). The lipid specificity of duramycin was not established. The present study indicates that both duramycin and cinnamycin exclusively bind to ethanolamine phospholipids
Izabela I Rzeźnicka et al.
Langmuir : the ACS journal of surfaces and colloids, 26(20), 16055-16062 (2010-09-30)
Duramycin is a small tetracyclic peptide which binds specifically to ethanolamine phospholipids (PE). In this study, we used lipid monolayers consisting of 1-palmitoyl-2-oleoyl phosphatidylethanolamine (POPE) and various phosphatidylcholines (PC) to investigate the effect of duramycin on the organization of lipids
M M Cloutier et al.
Membrane biochemistry, 10(2), 107-118 (1993-04-01)
Duramycin increases short-circuit current (Isc) and net Cl- secretion in tracheal epithelium. We measured the intracellular free calcium ([Ca2+]i) response to duramycin using Indo-1 and bovine and canine tracheal cell suspensions, and the effect of an intracellular calcium chelator, BAPTA
商品
Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.
由于细菌耐药性和新出现的传染病成为人类的潜在威胁，核糖体合成的抗菌肽已成为抗生素研究的一个有前途的重点领域。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持