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Merck
CN

L9756

(−)-四咪唑 盐酸盐

powder, ≥99% (GC)

别名:

L（−）- 2，3，5，6-四氢-6-苯基咪唑并[2，1-b]噻唑 盐酸盐, 左旋咪唑 盐酸盐, （S）-（−）-6-苯基-2，3，5，6-四氢咪唑并[2，1-b]噻唑 盐酸盐

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关于此项目

经验公式（希尔记法）:
C11H12N2S · HCl
化学文摘社编号:
16595-80-5
分子量:
240.75
Beilstein:
4358988
EC 号:
240-654-6
MDL编号:
MFCD00012675
UNSPSC代码:
12352202
PubChem化学物质编号:
24278526
NACRES:
NA.77

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产品名称

(−)-四咪唑 盐酸盐, ≥99% (GC)

生物来源

synthetic (organic)

方案

≥99% (GC)

表单

powder

mp

228-230 °C

溶解性

water: 50 mg/mL, clear, colorless to faintly yellow

抗生素抗菌谱

parasites

作用机制

enzyme | inhibits

SMILES字符串

Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1

InChI key

LAZPBGZRMVRFKY-HNCPQSOCSA-N

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应用

适用于抑制各种哺乳动物碱性磷酸酶（例如，肝、肾、胎盘、骨和肿瘤）。
肠道碱性磷酸酶仅受到轻微抑制。
不适合兽医使用。

生化/生理作用

根据一些可控因素，同时显示免疫刺激和免疫抑制作用。治疗蛔虫病（钩虫感染）非常有效。可用于结肠直肠癌的化疗，可能是由于其刺激IL-1 产生和巨噬细胞的直接激活。

其他说明

盐酸左旋咪唑可以 50mg/mL的浓度溶于水，产生澄清、无色的溶液。 在2-8℃ 下，溶液稳定保存约 1个月。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P301 + P310 + P330

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000435886
0000435908
0000435908
0000435886
0000433184

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Bioorganic & medicinal chemistry, 17(20), 7290-7300 (2009-09-29)
Presence of basic calcium phosphate in knee joints of osteoarthritis patients could be prevented by inhibiting tissue non-specific alkaline phosphatase (TNAP) activity. Levamisole or the L stereoisomer of tetramisole (a known TNAP inhibitor) has been used as a treatment for
Lei Chang et al.
Bioorganic & medicinal chemistry letters, 21(8), 2297-2301 (2011-03-23)
Pathological calcifications induced by deposition of basic phosphate crystals or hydroxyapatite (HA) on soft tissues are a large family of diseases comprising of ankylosing spondylitis (AS), end-stage osteoarthritis (OA) and vascular calcification. High activity of tissue non-specific alkaline phosphatase (TNAP)
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Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to
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实验方案

Immunohistochemistry Procedure

Use this protocol to for the entire immunohistochemistry (IHC) procedure through staining and visualization of specific antigens in paraffin-embedded tissue sections.

免疫组织化学操作步骤

本实验方案通过对石蜡包埋的组织切片中的特定抗原进行染色和成像，完成整个免疫组织化学（IHC）操作步骤。

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